Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to Medical Research Council Dyspnea Grade
Objective: To investigate the relations between Medical Research Council (MRC) dyspnea grade and peripheral muscle force, activities of daily living (ADL) performance, health status, lung function, and exercise capacity in subjects with idiopathic pulmonary fibrosis (IPF). Design: Prospective cross-...
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| Format: | Journal Article |
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W.B. Saunders Co.
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/3469 |
| _version_ | 1848744240603987968 |
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| author | Kozu, R. Jenkins, Susan Senjyu, H. |
| author_facet | Kozu, R. Jenkins, Susan Senjyu, H. |
| author_sort | Kozu, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: To investigate the relations between Medical Research Council (MRC) dyspnea grade and peripheral muscle force, activities of daily living (ADL) performance, health status, lung function, and exercise capacity in subjects with idiopathic pulmonary fibrosis (IPF). Design: Prospective cross-sectional observational study. Setting: University hospital. Participants: Subjects with IPF (N=65, 46 men) in a stable clinical state with a mean age of 68±7 years. Interventions: Not applicable. Main Outcome Measures: Right ventricular systolic pressure (RVSP) via transthoracic echocardiography, pulmonary function, isometric quadriceps force (QF) and handgrip force (HF), 6-minute walk distance (6MWD), ADL score, and health status (Medical Outcomes Study 36-Item Short-Form Health Survey [SF-36]) were assessed and compared between subjects grouped according to MRC grade. Results: Of the participants, 16 were in MRC grade 2, 17 were in MRC grade 3, 17 were in MRC grade 4, and 15 were in MRC grade 5. RVSP, pulmonary function, QF, HF, 6MWD, ADL, and SF-36 scores decreased with increasing MRC grade (all P<.001). All measures were lower (P<.05) in subjects with grades 4 and 5 than subjects with grades 2 and 3. Strong associations were found between MRC grade and 6MWD (ρ=−.89, P=.001) and ADL score (ρ=−.82, P=.001). MRC grade was also associated with RVSP, pulmonary function, QF, and HF (all ρ≥.56, P=.001). Conclusions: The MRC dyspnea scale provides a simple and useful method of categorizing individuals with IPF with respect to their activity limitation and may assist in understanding the impact of IPF on an individual. |
| first_indexed | 2025-11-14T05:58:19Z |
| format | Journal Article |
| id | curtin-20.500.11937-3469 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T05:58:19Z |
| publishDate | 2014 |
| publisher | W.B. Saunders Co. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-34692018-03-29T09:05:25Z Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to Medical Research Council Dyspnea Grade Kozu, R. Jenkins, Susan Senjyu, H. Rehabilitation Dyspnea Idiopathic pulmonary fibrosis Objective: To investigate the relations between Medical Research Council (MRC) dyspnea grade and peripheral muscle force, activities of daily living (ADL) performance, health status, lung function, and exercise capacity in subjects with idiopathic pulmonary fibrosis (IPF). Design: Prospective cross-sectional observational study. Setting: University hospital. Participants: Subjects with IPF (N=65, 46 men) in a stable clinical state with a mean age of 68±7 years. Interventions: Not applicable. Main Outcome Measures: Right ventricular systolic pressure (RVSP) via transthoracic echocardiography, pulmonary function, isometric quadriceps force (QF) and handgrip force (HF), 6-minute walk distance (6MWD), ADL score, and health status (Medical Outcomes Study 36-Item Short-Form Health Survey [SF-36]) were assessed and compared between subjects grouped according to MRC grade. Results: Of the participants, 16 were in MRC grade 2, 17 were in MRC grade 3, 17 were in MRC grade 4, and 15 were in MRC grade 5. RVSP, pulmonary function, QF, HF, 6MWD, ADL, and SF-36 scores decreased with increasing MRC grade (all P<.001). All measures were lower (P<.05) in subjects with grades 4 and 5 than subjects with grades 2 and 3. Strong associations were found between MRC grade and 6MWD (ρ=−.89, P=.001) and ADL score (ρ=−.82, P=.001). MRC grade was also associated with RVSP, pulmonary function, QF, and HF (all ρ≥.56, P=.001). Conclusions: The MRC dyspnea scale provides a simple and useful method of categorizing individuals with IPF with respect to their activity limitation and may assist in understanding the impact of IPF on an individual. 2014 Journal Article http://hdl.handle.net/20.500.11937/3469 10.1016/j.apmr.2014.01.016 W.B. Saunders Co. restricted |
| spellingShingle | Rehabilitation Dyspnea Idiopathic pulmonary fibrosis Kozu, R. Jenkins, Susan Senjyu, H. Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to Medical Research Council Dyspnea Grade |
| title | Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to Medical Research Council Dyspnea Grade |
| title_full | Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to Medical Research Council Dyspnea Grade |
| title_fullStr | Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to Medical Research Council Dyspnea Grade |
| title_full_unstemmed | Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to Medical Research Council Dyspnea Grade |
| title_short | Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to Medical Research Council Dyspnea Grade |
| title_sort | evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to medical research council dyspnea grade |
| topic | Rehabilitation Dyspnea Idiopathic pulmonary fibrosis |
| url | http://hdl.handle.net/20.500.11937/3469 |