The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa
The 'perfect storm' of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections. Interruption of bacterial cell-to-cell communication signalling (Quorum Sens...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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Royal Society of Chemistry
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/34685 |
| _version_ | 1848754290665979904 |
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| author | Shanahan, R. Reen, F. Cano, R. O'Gara, Fergal McGlacken, G. |
| author_facet | Shanahan, R. Reen, F. Cano, R. O'Gara, Fergal McGlacken, G. |
| author_sort | Shanahan, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The 'perfect storm' of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections. Interruption of bacterial cell-to-cell communication signalling (Quorum Sensing), thus neutralizing virulence in pathogenic bacteria, is a growing area. 2-Alkyl-4-quinolones, HHQ and PQS, play a key role in the quorum sensing circuitry of P. aeruginosa. We report a new set of isosteres of 2-heptyl-6-nitroquinolin-4-one, with alterations at C-3, and evaluate the key structural requirements for agonistic and antagonistic activity in Pseudomonas aeruginosa. |
| first_indexed | 2025-11-14T08:38:04Z |
| format | Journal Article |
| id | curtin-20.500.11937-34685 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:38:04Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-346852017-09-13T15:24:47Z The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa Shanahan, R. Reen, F. Cano, R. O'Gara, Fergal McGlacken, G. The 'perfect storm' of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections. Interruption of bacterial cell-to-cell communication signalling (Quorum Sensing), thus neutralizing virulence in pathogenic bacteria, is a growing area. 2-Alkyl-4-quinolones, HHQ and PQS, play a key role in the quorum sensing circuitry of P. aeruginosa. We report a new set of isosteres of 2-heptyl-6-nitroquinolin-4-one, with alterations at C-3, and evaluate the key structural requirements for agonistic and antagonistic activity in Pseudomonas aeruginosa. 2017 Journal Article http://hdl.handle.net/20.500.11937/34685 10.1039/C6OB01930G Royal Society of Chemistry restricted |
| spellingShingle | Shanahan, R. Reen, F. Cano, R. O'Gara, Fergal McGlacken, G. The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa |
| title | The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa |
| title_full | The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa |
| title_fullStr | The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa |
| title_full_unstemmed | The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa |
| title_short | The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa |
| title_sort | requirements at the c-3 position of alkylquinolones for signalling in pseudomonas aeruginosa |
| url | http://hdl.handle.net/20.500.11937/34685 |