Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus–Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver
Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is common in Asia, but the effects of antiretroviral therapy (ART) are unclear. Histopathological changes in the liver are described in a prospective study of HCV-seropositive HIV-infected patients at Cipto Mangunkusomo...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Oxford University Press
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/34325 |
| _version_ | 1848754192120807424 |
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| author | Gani, R. Yunihastuti, E. Krishnuhoni, E. Saraswati, H. Djauzi, S. Lesmana, L. Lee, S. Price, Patricia |
| author_facet | Gani, R. Yunihastuti, E. Krishnuhoni, E. Saraswati, H. Djauzi, S. Lesmana, L. Lee, S. Price, Patricia |
| author_sort | Gani, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is common in Asia, but the effects of antiretroviral therapy (ART) are unclear. Histopathological changes in the liver are described in a prospective study of HCV-seropositive HIV-infected patients at Cipto Mangunkusomo Hospital (Jakarta, Indonesia). Liver biopsy specimens were collected at baseline (n = 48) and 48 weeks (n = 34). Ishak scores showed mild but detectable inflammation and/ or fibrosis. Levels of portal inflammation declined during ART (P = .03), whereas fibrosis remained (P = .11). Portal infiltration of CD4+ cells increased during ART (P < .0001), whereas infiltration of CD8+ cells subsided. Numbers of CD4+ cells in the liver at baseline correlated with circulating CD4+ T-cell counts (P = .03–.05). Numbers of liver-infiltrating CD4+ and CD8+ cells at baseline were not associates with subsequent experience of an immune restoration disease, which is defined by a rise in alanine transaminase levels during ART. |
| first_indexed | 2025-11-14T08:36:30Z |
| format | Journal Article |
| id | curtin-20.500.11937-34325 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:36:30Z |
| publishDate | 2014 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-343252017-09-13T15:14:33Z Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus–Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver Gani, R. Yunihastuti, E. Krishnuhoni, E. Saraswati, H. Djauzi, S. Lesmana, L. Lee, S. Price, Patricia antiretroviral therapy HIV liver pathology co-infection hepatitis C Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is common in Asia, but the effects of antiretroviral therapy (ART) are unclear. Histopathological changes in the liver are described in a prospective study of HCV-seropositive HIV-infected patients at Cipto Mangunkusomo Hospital (Jakarta, Indonesia). Liver biopsy specimens were collected at baseline (n = 48) and 48 weeks (n = 34). Ishak scores showed mild but detectable inflammation and/ or fibrosis. Levels of portal inflammation declined during ART (P = .03), whereas fibrosis remained (P = .11). Portal infiltration of CD4+ cells increased during ART (P < .0001), whereas infiltration of CD8+ cells subsided. Numbers of CD4+ cells in the liver at baseline correlated with circulating CD4+ T-cell counts (P = .03–.05). Numbers of liver-infiltrating CD4+ and CD8+ cells at baseline were not associates with subsequent experience of an immune restoration disease, which is defined by a rise in alanine transaminase levels during ART. 2014 Journal Article http://hdl.handle.net/20.500.11937/34325 10.1093/infdis/jiu118 Oxford University Press unknown |
| spellingShingle | antiretroviral therapy HIV liver pathology co-infection hepatitis C Gani, R. Yunihastuti, E. Krishnuhoni, E. Saraswati, H. Djauzi, S. Lesmana, L. Lee, S. Price, Patricia Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus–Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver |
| title | Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus–Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver |
| title_full | Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus–Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver |
| title_fullStr | Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus–Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver |
| title_full_unstemmed | Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus–Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver |
| title_short | Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus–Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver |
| title_sort | periportal cd4+ cell infiltration increases in hiv/hepatitis c virus–coinfected patients commencing art, whereas cd8+ cells clear from the liver |
| topic | antiretroviral therapy HIV liver pathology co-infection hepatitis C |
| url | http://hdl.handle.net/20.500.11937/34325 |