Surprising performance of alginate beads for the release of low-molecular-weight drugs
The model of low-molecular-weight drugs has been encapsulated within alginate beads hardened with calcium chloride. The drug's release kinetic using 3% (w/v) alginate has shown a surprising behavior after 2 h, where the release kinetic was shifted from Fickian to case II transport mechanism con...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
John Wiley and Sons Inc
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/34087 |
| _version_ | 1848754127470854144 |
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| author | Elnashar, Magdy Yassin, M. El-Fetouh Abdel Moneim, A. Bary, E. |
| author_facet | Elnashar, Magdy Yassin, M. El-Fetouh Abdel Moneim, A. Bary, E. |
| author_sort | Elnashar, Magdy |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The model of low-molecular-weight drugs has been encapsulated within alginate beads hardened with calcium chloride. The drug's release kinetic using 3% (w/v) alginate has shown a surprising behavior after 2 h, where the release kinetic was shifted from Fickian to case II transport mechanism contradicting other authors like Akihiko et al. (J Control Release 1999, 58, 21). To support this finding, we studied the swelling of dried gel beads of 2 and 3% (w/v) alginate, which showed a sudden decrease in the swelling of 3% (w/v) alginate after 2 h due to a partial bursting of the beads. This sudden bursting was clearly observed using the optical microscope to emphasize the new findings. Calcium alginate beads revealed pH sensitivity, where 2% (w/v) alginate beads showed a maximum swelling of 5000% in alkaline medium at pH 7.4, compared with a negligible swelling percent of 60% in acidic medium (pH 1.2). Accordingly, it could be a good candidate for targeting smart and low-molecular-weight drugs to the intestine. © 2010 Wiley Periodicals, Inc. |
| first_indexed | 2025-11-14T08:35:28Z |
| format | Journal Article |
| id | curtin-20.500.11937-34087 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:35:28Z |
| publishDate | 2010 |
| publisher | John Wiley and Sons Inc |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-340872017-09-13T15:12:28Z Surprising performance of alginate beads for the release of low-molecular-weight drugs Elnashar, Magdy Yassin, M. El-Fetouh Abdel Moneim, A. Bary, E. The model of low-molecular-weight drugs has been encapsulated within alginate beads hardened with calcium chloride. The drug's release kinetic using 3% (w/v) alginate has shown a surprising behavior after 2 h, where the release kinetic was shifted from Fickian to case II transport mechanism contradicting other authors like Akihiko et al. (J Control Release 1999, 58, 21). To support this finding, we studied the swelling of dried gel beads of 2 and 3% (w/v) alginate, which showed a sudden decrease in the swelling of 3% (w/v) alginate after 2 h due to a partial bursting of the beads. This sudden bursting was clearly observed using the optical microscope to emphasize the new findings. Calcium alginate beads revealed pH sensitivity, where 2% (w/v) alginate beads showed a maximum swelling of 5000% in alkaline medium at pH 7.4, compared with a negligible swelling percent of 60% in acidic medium (pH 1.2). Accordingly, it could be a good candidate for targeting smart and low-molecular-weight drugs to the intestine. © 2010 Wiley Periodicals, Inc. 2010 Journal Article http://hdl.handle.net/20.500.11937/34087 10.1002/app.31836 John Wiley and Sons Inc restricted |
| spellingShingle | Elnashar, Magdy Yassin, M. El-Fetouh Abdel Moneim, A. Bary, E. Surprising performance of alginate beads for the release of low-molecular-weight drugs |
| title | Surprising performance of alginate beads for the release of low-molecular-weight drugs |
| title_full | Surprising performance of alginate beads for the release of low-molecular-weight drugs |
| title_fullStr | Surprising performance of alginate beads for the release of low-molecular-weight drugs |
| title_full_unstemmed | Surprising performance of alginate beads for the release of low-molecular-weight drugs |
| title_short | Surprising performance of alginate beads for the release of low-molecular-weight drugs |
| title_sort | surprising performance of alginate beads for the release of low-molecular-weight drugs |
| url | http://hdl.handle.net/20.500.11937/34087 |