Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses
Cytokine gene polymorphisms affect vaccine responses and gender-specific effects are known for many phenotypes. Therefore, this study investigated gender-specific effects of cytokine gene polymorphisms on vaccine responses. In 263 2-year-old subjects selected for parental history of atopy, boys with...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/34065 |
| _version_ | 1848754120619458560 |
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| author | Baynam, G. Zhang, Guicheng Khoo, S. Sly, P. Holt, P. Goldblatt, J. Le Souëf, P. |
| author_facet | Baynam, G. Zhang, Guicheng Khoo, S. Sly, P. Holt, P. Goldblatt, J. Le Souëf, P. |
| author_sort | Baynam, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Cytokine gene polymorphisms affect vaccine responses and gender-specific effects are known for many phenotypes. Therefore, this study investigated gender-specific effects of cytokine gene polymorphisms on vaccine responses. In 263 2-year-old subjects selected for parental history of atopy, boys with IL-4 C-589T and IL-4Ra I50V genotypes associated with atopy had increased Diptheria Toxoid (DiphTox) and Tetanus Toxoid (TetTox) responses compared with the remaining alleles (IL-4 C-589T: DipTox p = 0.01, TetTox p = 0.04; IL-4Ra.I50V: DipTox p = 0.04, TetTox p = 0.08). Contrastingly, girls with IL-10 -592C genotypes associated with atopy had lower levels of DiphTox (p = 0.03) and TetTox (p = 0.02) responses compared with the remaining allele. Additionally, interaction effects were found for IL-4 C-589T (p = 0.01) and IL-4Ra I50V (p = 0.04) polymorphisms. In conclusion, these findings support the interaction of primary genetic and modifying factors on vaccine responses and the importance of atopic genetics to these responses. © 2008 Elsevier Ltd. All rights reserved. |
| first_indexed | 2025-11-14T08:35:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-34065 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:35:22Z |
| publishDate | 2008 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-340652017-09-13T15:06:36Z Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses Baynam, G. Zhang, Guicheng Khoo, S. Sly, P. Holt, P. Goldblatt, J. Le Souëf, P. Cytokine gene polymorphisms affect vaccine responses and gender-specific effects are known for many phenotypes. Therefore, this study investigated gender-specific effects of cytokine gene polymorphisms on vaccine responses. In 263 2-year-old subjects selected for parental history of atopy, boys with IL-4 C-589T and IL-4Ra I50V genotypes associated with atopy had increased Diptheria Toxoid (DiphTox) and Tetanus Toxoid (TetTox) responses compared with the remaining alleles (IL-4 C-589T: DipTox p = 0.01, TetTox p = 0.04; IL-4Ra.I50V: DipTox p = 0.04, TetTox p = 0.08). Contrastingly, girls with IL-10 -592C genotypes associated with atopy had lower levels of DiphTox (p = 0.03) and TetTox (p = 0.02) responses compared with the remaining allele. Additionally, interaction effects were found for IL-4 C-589T (p = 0.01) and IL-4Ra I50V (p = 0.04) polymorphisms. In conclusion, these findings support the interaction of primary genetic and modifying factors on vaccine responses and the importance of atopic genetics to these responses. © 2008 Elsevier Ltd. All rights reserved. 2008 Journal Article http://hdl.handle.net/20.500.11937/34065 10.1016/j.vaccine.2008.05.011 Elsevier restricted |
| spellingShingle | Baynam, G. Zhang, Guicheng Khoo, S. Sly, P. Holt, P. Goldblatt, J. Le Souëf, P. Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses |
| title | Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses |
| title_full | Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses |
| title_fullStr | Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses |
| title_full_unstemmed | Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses |
| title_short | Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses |
| title_sort | gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses |
| url | http://hdl.handle.net/20.500.11937/34065 |