The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism
Regulation of testosterone and luteinizing hormone (LH) is tightly linked, and following reproductive senescence, sex hormone reductions are coupled with elevated gonadotropin levels. This chapter focuses on the sex hormone, testosterone, and the gonadotropin, LH. It outlines the role of these hormo...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Book Chapter |
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Cambridge University Press
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/34052 |
| _version_ | 1848754116434591744 |
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| author | Verdile, Giuseppe Martins, R. |
| author2 | Eef Hogervorst |
| author_facet | Eef Hogervorst Verdile, Giuseppe Martins, R. |
| author_sort | Verdile, Giuseppe |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Regulation of testosterone and luteinizing hormone (LH) is tightly linked, and following reproductive senescence, sex hormone reductions are coupled with elevated gonadotropin levels. This chapter focuses on the sex hormone, testosterone, and the gonadotropin, LH. It outlines the role of these hormones in regulating beta-amyloid (Aβ) metabolism and amyloid precursor protein (APP) processing and discusses their potential as targets for developing effective therapeutic agents for Alzheimer's disease (AD). Sex steroid production is under the control of complex feedback loops within the hypothalamic-pituitary-ovary/ gonadal axis that regulate the levels of the pituitary gonadotropins, follicle stimulating hormone (FSH), and LH, in turn controlling estrogen and testosterone levels. The relative contributions of LH and testosterone to AD remain a challenge to be overcome by further experimentation. Given the diverse actions of the reproductive hormones, combinational hormone therapy may prove to be more efficacious in the prevention of AD. |
| first_indexed | 2025-11-14T08:35:18Z |
| format | Book Chapter |
| id | curtin-20.500.11937-34052 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:35:18Z |
| publishDate | 2009 |
| publisher | Cambridge University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-340522022-12-09T06:09:42Z The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism Verdile, Giuseppe Martins, R. Eef Hogervorst W. Henderson Robert B. Gibbs Roberta Diaz Brinton Regulation of testosterone and luteinizing hormone (LH) is tightly linked, and following reproductive senescence, sex hormone reductions are coupled with elevated gonadotropin levels. This chapter focuses on the sex hormone, testosterone, and the gonadotropin, LH. It outlines the role of these hormones in regulating beta-amyloid (Aβ) metabolism and amyloid precursor protein (APP) processing and discusses their potential as targets for developing effective therapeutic agents for Alzheimer's disease (AD). Sex steroid production is under the control of complex feedback loops within the hypothalamic-pituitary-ovary/ gonadal axis that regulate the levels of the pituitary gonadotropins, follicle stimulating hormone (FSH), and LH, in turn controlling estrogen and testosterone levels. The relative contributions of LH and testosterone to AD remain a challenge to be overcome by further experimentation. Given the diverse actions of the reproductive hormones, combinational hormone therapy may prove to be more efficacious in the prevention of AD. 2009 Book Chapter http://hdl.handle.net/20.500.11937/34052 10.1017/CBO9780511635700.028 Cambridge University Press restricted |
| spellingShingle | Verdile, Giuseppe Martins, R. The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism |
| title | The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism |
| title_full | The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism |
| title_fullStr | The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism |
| title_full_unstemmed | The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism |
| title_short | The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism |
| title_sort | role of gonadotropins and testosterone in the regulation of beta amyloid metabolism |
| url | http://hdl.handle.net/20.500.11937/34052 |