Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy
Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR) whi...
| Main Authors: | , , , |
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| Format: | Journal Article |
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BioScientifica
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/33783 |
| _version_ | 1848754042607501312 |
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| author | Elahy, M. Baindur-Hudson, S. Newsholme, Philip Dass, Crispin |
| author_facet | Elahy, M. Baindur-Hudson, S. Newsholme, Philip Dass, Crispin |
| author_sort | Elahy, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR) which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory and neuroprotective properties. |
| first_indexed | 2025-11-14T08:34:07Z |
| format | Journal Article |
| id | curtin-20.500.11937-33783 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:34:07Z |
| publishDate | 2014 |
| publisher | BioScientifica |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-337832017-09-13T15:32:25Z Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy Elahy, M. Baindur-Hudson, S. Newsholme, Philip Dass, Crispin Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR) which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory and neuroprotective properties. 2014 Journal Article http://hdl.handle.net/20.500.11937/33783 10.1530/JOE-14-0065 BioScientifica unknown |
| spellingShingle | Elahy, M. Baindur-Hudson, S. Newsholme, Philip Dass, Crispin Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy |
| title | Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy |
| title_full | Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy |
| title_fullStr | Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy |
| title_full_unstemmed | Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy |
| title_short | Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy |
| title_sort | mechanisms of pedf-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy |
| url | http://hdl.handle.net/20.500.11937/33783 |