Impact of Gemcitabine Chemotherapy and 3-Dimensional Conformal Radiation Therapy/5-Fluorouracil on Quality of life of patients Managed for Pancreatic Cancer
Purpose: To report quality of life (QOL) results for patients receiving chemoradiation therapyfor pancreatic cancer.Methods and Materials: Eligible patients (nZ41 locally advanced, nZ22 postsurgery) enteredthe B9E-AY-S168 study and received 1 cycle of induction gemcitabine (1000 mg/m2 weekly 3with 1...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Elsevier Inc.
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/33732 |
| _version_ | 1848754028761055232 |
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| author | Short, Michelle Goldstein, D. Halkett, Georgia Reece, W. Borg, M. Zissiadis, Y. Kneebone, A. Spry, Nigel |
| author_facet | Short, Michelle Goldstein, D. Halkett, Georgia Reece, W. Borg, M. Zissiadis, Y. Kneebone, A. Spry, Nigel |
| author_sort | Short, Michelle |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purpose: To report quality of life (QOL) results for patients receiving chemoradiation therapyfor pancreatic cancer.Methods and Materials: Eligible patients (nZ41 locally advanced, nZ22 postsurgery) enteredthe B9E-AY-S168 study and received 1 cycle of induction gemcitabine (1000 mg/m2 weekly 3with 1-week break) followed by 3-dimensional conformal radiation therapy (RT) (54 Gy locallyadvanced and 45 Gy postsurgery) and concomitant continuous-infusion 5-fluorouracil (5FU)(200 mg/m2/d throughout RT). After 4 weeks, patients received an additional 3 cycles of consolidationgemcitabine chemotherapy. Patients completed the European Organization for Researchand Treatment of Cancer QLQ-C30 and QLQ-PAN26 questionnaires at baseline, beforeRT/5FU, at end of RT/5FU, before consolidation gemcitabine, and at treatment completion.Results: The patterns of change in global QOL scores differed between groups. In the locallyadvanced group global QOL scores were þ13, þ8, þ3, and þ1 compared with baseline beforeRT/5FU (PZ.008), at end of RT/5FU, before consolidation gemcitabine, and at treatmentcompletion, respectively. In the postsurgery group, global QOL scores were 3, þ4, þ15,and þ17 compared with baseline at the same time points, with a significant improvement inglobal QOL before consolidation gemcitabine (PZ.03). No significant declines in globalQOL were reported by either cohort. |
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| format | Journal Article |
| id | curtin-20.500.11937-33732 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:33:54Z |
| publishDate | 2013 |
| publisher | Elsevier Inc. |
| recordtype | eprints |
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| spelling | curtin-20.500.11937-337322017-09-13T15:33:14Z Impact of Gemcitabine Chemotherapy and 3-Dimensional Conformal Radiation Therapy/5-Fluorouracil on Quality of life of patients Managed for Pancreatic Cancer Short, Michelle Goldstein, D. Halkett, Georgia Reece, W. Borg, M. Zissiadis, Y. Kneebone, A. Spry, Nigel Purpose: To report quality of life (QOL) results for patients receiving chemoradiation therapyfor pancreatic cancer.Methods and Materials: Eligible patients (nZ41 locally advanced, nZ22 postsurgery) enteredthe B9E-AY-S168 study and received 1 cycle of induction gemcitabine (1000 mg/m2 weekly 3with 1-week break) followed by 3-dimensional conformal radiation therapy (RT) (54 Gy locallyadvanced and 45 Gy postsurgery) and concomitant continuous-infusion 5-fluorouracil (5FU)(200 mg/m2/d throughout RT). After 4 weeks, patients received an additional 3 cycles of consolidationgemcitabine chemotherapy. Patients completed the European Organization for Researchand Treatment of Cancer QLQ-C30 and QLQ-PAN26 questionnaires at baseline, beforeRT/5FU, at end of RT/5FU, before consolidation gemcitabine, and at treatment completion.Results: The patterns of change in global QOL scores differed between groups. In the locallyadvanced group global QOL scores were þ13, þ8, þ3, and þ1 compared with baseline beforeRT/5FU (PZ.008), at end of RT/5FU, before consolidation gemcitabine, and at treatmentcompletion, respectively. In the postsurgery group, global QOL scores were 3, þ4, þ15,and þ17 compared with baseline at the same time points, with a significant improvement inglobal QOL before consolidation gemcitabine (PZ.03). No significant declines in globalQOL were reported by either cohort. 2013 Journal Article http://hdl.handle.net/20.500.11937/33732 10.1016/j.ijrobp.2012.03.003 Elsevier Inc. fulltext |
| spellingShingle | Short, Michelle Goldstein, D. Halkett, Georgia Reece, W. Borg, M. Zissiadis, Y. Kneebone, A. Spry, Nigel Impact of Gemcitabine Chemotherapy and 3-Dimensional Conformal Radiation Therapy/5-Fluorouracil on Quality of life of patients Managed for Pancreatic Cancer |
| title | Impact of Gemcitabine Chemotherapy and 3-Dimensional Conformal Radiation Therapy/5-Fluorouracil on Quality of life of patients Managed for Pancreatic Cancer |
| title_full | Impact of Gemcitabine Chemotherapy and 3-Dimensional Conformal Radiation Therapy/5-Fluorouracil on Quality of life of patients Managed for Pancreatic Cancer |
| title_fullStr | Impact of Gemcitabine Chemotherapy and 3-Dimensional Conformal Radiation Therapy/5-Fluorouracil on Quality of life of patients Managed for Pancreatic Cancer |
| title_full_unstemmed | Impact of Gemcitabine Chemotherapy and 3-Dimensional Conformal Radiation Therapy/5-Fluorouracil on Quality of life of patients Managed for Pancreatic Cancer |
| title_short | Impact of Gemcitabine Chemotherapy and 3-Dimensional Conformal Radiation Therapy/5-Fluorouracil on Quality of life of patients Managed for Pancreatic Cancer |
| title_sort | impact of gemcitabine chemotherapy and 3-dimensional conformal radiation therapy/5-fluorouracil on quality of life of patients managed for pancreatic cancer |
| url | http://hdl.handle.net/20.500.11937/33732 |