Synthesis of a benzene-annulated analogue of resolving E1 and other lipid mediators
The resolvins are a class of short-lived, naturally occurring compounds with potent anti-inflammatory effects. Using a sequential Sonogashira-Stille reaction, the formal total synthesis of resolvin E1 and the synthesis of a benzene annulated analogue of this compound were completed. The fusion of th...
| Main Author: | |
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| Format: | Thesis |
| Language: | English |
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Curtin University
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/337 |
| _version_ | 1848743350077751296 |
|---|---|
| author | Lombardo, Daniel Mario |
| author_facet | Lombardo, Daniel Mario |
| author_sort | Lombardo, Daniel Mario |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The resolvins are a class of short-lived, naturally occurring compounds with potent anti-inflammatory effects. Using a sequential Sonogashira-Stille reaction, the formal total synthesis of resolvin E1 and the synthesis of a benzene annulated analogue of this compound were completed. The fusion of the benzene ring improves the stability and retains the molecules activity towards the BLT-1 receptor. |
| first_indexed | 2025-11-14T05:44:10Z |
| format | Thesis |
| id | curtin-20.500.11937-337 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:44:10Z |
| publishDate | 2015 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-3372017-02-20T06:41:50Z Synthesis of a benzene-annulated analogue of resolving E1 and other lipid mediators Lombardo, Daniel Mario The resolvins are a class of short-lived, naturally occurring compounds with potent anti-inflammatory effects. Using a sequential Sonogashira-Stille reaction, the formal total synthesis of resolvin E1 and the synthesis of a benzene annulated analogue of this compound were completed. The fusion of the benzene ring improves the stability and retains the molecules activity towards the BLT-1 receptor. 2015 Thesis http://hdl.handle.net/20.500.11937/337 en Curtin University fulltext |
| spellingShingle | Lombardo, Daniel Mario Synthesis of a benzene-annulated analogue of resolving E1 and other lipid mediators |
| title | Synthesis of a benzene-annulated analogue of resolving E1 and other lipid mediators |
| title_full | Synthesis of a benzene-annulated analogue of resolving E1 and other lipid mediators |
| title_fullStr | Synthesis of a benzene-annulated analogue of resolving E1 and other lipid mediators |
| title_full_unstemmed | Synthesis of a benzene-annulated analogue of resolving E1 and other lipid mediators |
| title_short | Synthesis of a benzene-annulated analogue of resolving E1 and other lipid mediators |
| title_sort | synthesis of a benzene-annulated analogue of resolving e1 and other lipid mediators |
| url | http://hdl.handle.net/20.500.11937/337 |