Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases.

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Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases.

We previously demonstrated elevated brain iron levels in myelinated structures and associated cells in a hemochromatosis Hfe (-/-) xTfr2 (mut) mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease...

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Bibliographic Details
Main Authors:	Heidari, M., Gerami, S., Bassett, B., Graham, Ross, Chua, A., Aryal, R., House, M., Collingwood, J., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, John, Trinder, D., Johnstone, D., Milward, E.
Format:	Journal Article
Published:	2016
Online Access:	http://hdl.handle.net/20.500.11937/3353

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