Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings
Vaginal rings are currently being investigated for delivery of HIV microbicides. However, vaginal rings are currently manufactured form hydrophobic polymers such as silicone elastomer and polyethylene vinyl acetate (PEVA), which do not permit release of hydrophilic microbicides such as the nucleotid...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Wiley
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/3337 |
| _version_ | 1848744203827281920 |
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| author | McConville, Christopher Major, Ian Friend, David Clark, Meredith Woolfson, A Malcolm, R |
| author_facet | McConville, Christopher Major, Ian Friend, David Clark, Meredith Woolfson, A Malcolm, R |
| author_sort | McConville, Christopher |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Vaginal rings are currently being investigated for delivery of HIV microbicides. However, vaginal rings are currently manufactured form hydrophobic polymers such as silicone elastomer and polyethylene vinyl acetate (PEVA), which do not permit release of hydrophilic microbicides such as the nucleotide reverse transcriptase inhibitor tenofovir. Biodegradable polymers such as polylactide (PLA) may help increase release rates by controlling polymer degradation rather than diffusion of the drug through the polymer. However, biodegradable polymers have limited flexibility making them unsuitable for use in the manufacture of vaginal rings. This study demonstrates that by blending PLA and PEVA together it is possible to achieve a blend that has flexibility similar to native PEVA but also allows for the release of tenofovir. |
| first_indexed | 2025-11-14T05:57:44Z |
| format | Journal Article |
| id | curtin-20.500.11937-3337 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T05:57:44Z |
| publishDate | 2012 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-33372017-09-13T16:06:41Z Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings McConville, Christopher Major, Ian Friend, David Clark, Meredith Woolfson, A Malcolm, R Vaginal rings are currently being investigated for delivery of HIV microbicides. However, vaginal rings are currently manufactured form hydrophobic polymers such as silicone elastomer and polyethylene vinyl acetate (PEVA), which do not permit release of hydrophilic microbicides such as the nucleotide reverse transcriptase inhibitor tenofovir. Biodegradable polymers such as polylactide (PLA) may help increase release rates by controlling polymer degradation rather than diffusion of the drug through the polymer. However, biodegradable polymers have limited flexibility making them unsuitable for use in the manufacture of vaginal rings. This study demonstrates that by blending PLA and PEVA together it is possible to achieve a blend that has flexibility similar to native PEVA but also allows for the release of tenofovir. 2012 Journal Article http://hdl.handle.net/20.500.11937/3337 10.1002/jbm.b.31919 Wiley restricted |
| spellingShingle | McConville, Christopher Major, Ian Friend, David Clark, Meredith Woolfson, A Malcolm, R Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings |
| title | Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings |
| title_full | Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings |
| title_fullStr | Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings |
| title_full_unstemmed | Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings |
| title_short | Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings |
| title_sort | development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings |
| url | http://hdl.handle.net/20.500.11937/3337 |