Does the combination of optimal substitutions at the C2-, N5- and N8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors?

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Does the combination of optimal substitutions at the C2-, N5- and N8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors?

In an attempt to study the optimal combination of a phenyl ring at the C2-position and different substituents at the N5- and N8-positions towards the selective modulation of human A3 adenosine receptors (hA3AR), we synthesized a new series of 2-para-(un)substituted-phenyl-pyrazolo-triazolo-pyrimidin...

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Bibliographic Details
Main Authors:	Cheong, S., Dolzhenko, Anton, Paoletta, S., Lee, E., Kachler, S., Federico, S., Klotz, K., Dolzhenko, A., Spalluto, G., Moro, S., Pastorin, G.
Format:	Journal Article
Published:	Elsevier 2011
Online Access:	http://hdl.handle.net/20.500.11937/33279

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