Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers
Ovarian cancer is one of the most lethal malignancies in women, as it is frequently detected at an advanced stage, and cancers often become refractory to chemotherapy. Evidence suggests that dysregulation of pro-apoptotic genes plays a key role in the onset of chemoresistance. The secreted Frizzled-...
| Main Authors: | , , , |
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| Format: | Journal Article |
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BioMed Central Ltd.
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/33260 |
| _version_ | 1848753895856144384 |
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| author | Saran, U. Arfuso, F. Zeps, N. Dharmarajan, Arunasalam |
| author_facet | Saran, U. Arfuso, F. Zeps, N. Dharmarajan, Arunasalam |
| author_sort | Saran, U. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Ovarian cancer is one of the most lethal malignancies in women, as it is frequently detected at an advanced stage, and cancers often become refractory to chemotherapy. Evidence suggests that dysregulation of pro-apoptotic genes plays a key role in the onset of chemoresistance. The secreted Frizzled-Related Protein (sFRP) family is pro-apoptotic and also a negative modulator of the Wnt signalling cascade. Studies have demonstrated that the re-expression of sFRPs, in particular sFRP4, is associated with a better prognosis, and that experimentally induced expression results in cell death. |
| first_indexed | 2025-11-14T08:31:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-33260 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:31:47Z |
| publishDate | 2012 |
| publisher | BioMed Central Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-332602017-09-13T16:08:23Z Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers Saran, U. Arfuso, F. Zeps, N. Dharmarajan, Arunasalam Tumour biopsy Ovarian cancer Secreted frizzled-related protein 4 Cisplatin Chemosensitivity Chemoresistance Ovarian cancer is one of the most lethal malignancies in women, as it is frequently detected at an advanced stage, and cancers often become refractory to chemotherapy. Evidence suggests that dysregulation of pro-apoptotic genes plays a key role in the onset of chemoresistance. The secreted Frizzled-Related Protein (sFRP) family is pro-apoptotic and also a negative modulator of the Wnt signalling cascade. Studies have demonstrated that the re-expression of sFRPs, in particular sFRP4, is associated with a better prognosis, and that experimentally induced expression results in cell death. 2012 Journal Article http://hdl.handle.net/20.500.11937/33260 10.1186/1471-2121-13-25 BioMed Central Ltd. fulltext |
| spellingShingle | Tumour biopsy Ovarian cancer Secreted frizzled-related protein 4 Cisplatin Chemosensitivity Chemoresistance Saran, U. Arfuso, F. Zeps, N. Dharmarajan, Arunasalam Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers |
| title | Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers |
| title_full | Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers |
| title_fullStr | Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers |
| title_full_unstemmed | Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers |
| title_short | Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers |
| title_sort | secreted frizzled-related protein 4 expression is positively associated with responsiveness to cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers |
| topic | Tumour biopsy Ovarian cancer Secreted frizzled-related protein 4 Cisplatin Chemosensitivity Chemoresistance |
| url | http://hdl.handle.net/20.500.11937/33260 |