Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment
Background: A number of composite outcomes have been developed to capture the perspective of the patient, clinician and objective measures of health in assessing heart failure outcomes. To date there has been a limited examination in the composition of these outcomes. Three commonly used scoring sys...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier Ireland Ltd.
2015
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/33197 |
| _version_ | 1848753878338633728 |
|---|---|
| author | Chang, Sungwon Davidson, P. Newton, Phillip Macdonald, P. Carrington, M. Marwick, T. Horowitz, J. Krum, H. Reid, Christopher Chan, Y. Scuffham, P. Sibbritt, D. Stewart, S. |
| author_facet | Chang, Sungwon Davidson, P. Newton, Phillip Macdonald, P. Carrington, M. Marwick, T. Horowitz, J. Krum, H. Reid, Christopher Chan, Y. Scuffham, P. Sibbritt, D. Stewart, S. |
| author_sort | Chang, Sungwon |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: A number of composite outcomes have been developed to capture the perspective of the patient, clinician and objective measures of health in assessing heart failure outcomes. To date there has been a limited examination in the composition of these outcomes. Three commonly used scoring systems in heart failure trials: Packer's composite, Patient Journey and the African American Heart Failure Trial (A-HeFT) scores were compared in assessing outcomes from the Which heart failure intervention is most cost-effective & consumer friendly in reducing hospital care (WHICH(?)) Trial. Comparability and interpretability of these outcomes and the influence of each component to the final outcome were examined. Despite all three composite outcomes incorporating mortality, hospitalisation and quality of life (QoL), the contribution of each individual component to the final outcomes differed. The component with the most influence in deteriorating condition for the Packer's composite was hospitalisation (67.7%), while in Patient Journey it was QoL (61.5%) and for A-HeFT composite score it was mortality (45.4%). Conclusions: The contribution made by each component varied in subtle, but important ways. This study emphasises the importance of understanding the value system of the composite outcomes to enable meaningful interpretation of results. |
| first_indexed | 2025-11-14T08:31:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-33197 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:31:31Z |
| publishDate | 2015 |
| publisher | Elsevier Ireland Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-331972017-09-13T15:28:50Z Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment Chang, Sungwon Davidson, P. Newton, Phillip Macdonald, P. Carrington, M. Marwick, T. Horowitz, J. Krum, H. Reid, Christopher Chan, Y. Scuffham, P. Sibbritt, D. Stewart, S. Outcome assessment Composite outcome Chronic heart failure Background: A number of composite outcomes have been developed to capture the perspective of the patient, clinician and objective measures of health in assessing heart failure outcomes. To date there has been a limited examination in the composition of these outcomes. Three commonly used scoring systems in heart failure trials: Packer's composite, Patient Journey and the African American Heart Failure Trial (A-HeFT) scores were compared in assessing outcomes from the Which heart failure intervention is most cost-effective & consumer friendly in reducing hospital care (WHICH(?)) Trial. Comparability and interpretability of these outcomes and the influence of each component to the final outcome were examined. Despite all three composite outcomes incorporating mortality, hospitalisation and quality of life (QoL), the contribution of each individual component to the final outcomes differed. The component with the most influence in deteriorating condition for the Packer's composite was hospitalisation (67.7%), while in Patient Journey it was QoL (61.5%) and for A-HeFT composite score it was mortality (45.4%). Conclusions: The contribution made by each component varied in subtle, but important ways. This study emphasises the importance of understanding the value system of the composite outcomes to enable meaningful interpretation of results. 2015 Journal Article http://hdl.handle.net/20.500.11937/33197 10.1016/j.ijcard.2015.03.071 Elsevier Ireland Ltd. restricted |
| spellingShingle | Outcome assessment Composite outcome Chronic heart failure Chang, Sungwon Davidson, P. Newton, Phillip Macdonald, P. Carrington, M. Marwick, T. Horowitz, J. Krum, H. Reid, Christopher Chan, Y. Scuffham, P. Sibbritt, D. Stewart, S. Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment |
| title | Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment |
| title_full | Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment |
| title_fullStr | Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment |
| title_full_unstemmed | Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment |
| title_short | Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment |
| title_sort | composite outcome measures in a pragmatic clinical trial of chronic heart failure management: a comparative assessment |
| topic | Outcome assessment Composite outcome Chronic heart failure |
| url | http://hdl.handle.net/20.500.11937/33197 |