Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A

Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A

Neutralizing antibodies (inhibitors) to replacement factor VIII (FVIII, either plasma derived or recombinant) impair the effective management of hemophilia A1. Individuals with hemophilia A due to major deletions of the FVIII gene (F8) lack antigenically cross-reactive material in their plasma (“CRM...

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Main Authors: Pandey, G., Yanover, C., Miller-Jenkins, L., Garfield, S., Cole, S., Curran, J., Moses, Eric, Rydz, N., Simhadri, V., Kimchi-Sarfaty, C., Lillicrap, D., Viel, K., Przytycka, T., Pierce, G., Howard, T., Sauna, Z., Lusher, J., Chitlur, M., Ameri, A., Natarajan, K., Iyer, R., Thompson, A., Watts, R., Kempton, C., Kessler, C., Barrett, J., Martin, E., Key, N., Kruse-Jarres, R., Lessinger, C., Pratt, K., Josephson, N., McRedmond, K., Withycombe, J., Walsh, C., Matthews, D., Mahlangu, J., Krause, A., Schwyzer, R., Thejpal, R., Rapiti, N., Goga, Y., Coetzee, M., Stones, D., Mann, K., Butenas, S., Almasy, L., Blangero, J., Carless, M., Raja, R., Reed, E.
Format: Journal Article
Published: 2013
Online Access:http://hdl.handle.net/20.500.11937/33146

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