Role for the terminal clasp of hiv-1 gp41 glycoprotein in the initiation of membrane fusion

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Role for the terminal clasp of hiv-1 gp41 glycoprotein in the initiation of membrane fusion

The binding by HIV-1 gp120 to CD4 and a chemokine receptor activates the membrane fusion glycoprotein, gp41. The fusion function of gp41 involves the refolding of its core into a 6-helix bundle, which apposes the lipophilic termini (the fusion peptide and transmembrane domain) and the associated cel...

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Bibliographic Details
Main Authors:	Lay, C., Ludlow, L., Stapleton, D., Bellamy-McIntyre, A., Ramsland, Paul, Drummer, H., Poumbourios, P.
Format:	Journal Article
Published:	2011
Online Access:	http://hdl.handle.net/20.500.11937/3310

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