Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level
Crystallization of L-cystine is a critical process in the pathogenesis of kidney stone formation in cystinuria, a disorder affecting more than 20 000 individuals in the United States alone. In an effort to elucidate the crystallization of L-cystine and the mode of action of tailored growth inhibitor...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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American Chemical Society
2015
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| Online Access: | http://purl.org/au-research/grants/arc/DP140101776 http://hdl.handle.net/20.500.11937/33037 |
| _version_ | 1848753834530177024 |
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| author | Shtukenberg, A. Poloni, L. Zhu, Z. An, Z. Bhandari, M. Song, P. Rohl, Andrew Kahr, B. Ward, M. |
| author_facet | Shtukenberg, A. Poloni, L. Zhu, Z. An, Z. Bhandari, M. Song, P. Rohl, Andrew Kahr, B. Ward, M. |
| author_sort | Shtukenberg, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Crystallization of L-cystine is a critical process in the pathogenesis of kidney stone formation in cystinuria, a disorder affecting more than 20 000 individuals in the United States alone. In an effort to elucidate the crystallization of L-cystine and the mode of action of tailored growth inhibitors that may constitute effective therapies, real-time in situ atomic force microscopy has been used to investigate the surface micromorphology and growth kinetics of the {0001} faces of L-cystine at various supersaturations and concentrations of the growth inhibitor L-cystine dimethylester (CDME). Crystal growth is actuated by screw dislocations on the {0001} L-cystine surface, producing hexagonal spiral hillocks that are a consequence of six interlacing spirals of anisotropic molecular layers. The high level of elastic stress in the immediate vicinity around the dislocation line results in a decrease in the step velocities and a corresponding increase in the spacing of steps. The kinetic curves acquired in the presence of CDME conform to the classical Cabrera–Vermilyea model. Anomalous birefringence in the {101̅0} growth sectors, combined with computational modeling, supports a high fidelity of stereospecific binding of CDME, in a unique orientation, exclusively at one of the six crystallographically unique projections on the {1010} plane. |
| first_indexed | 2025-11-14T08:30:49Z |
| format | Journal Article |
| id | curtin-20.500.11937-33037 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:30:49Z |
| publishDate | 2015 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-330372022-10-12T02:58:18Z Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level Shtukenberg, A. Poloni, L. Zhu, Z. An, Z. Bhandari, M. Song, P. Rohl, Andrew Kahr, B. Ward, M. kidney stone formation - atomic force microscope - crystallization kinetics Crystallization of L-cystine is a critical process in the pathogenesis of kidney stone formation in cystinuria, a disorder affecting more than 20 000 individuals in the United States alone. In an effort to elucidate the crystallization of L-cystine and the mode of action of tailored growth inhibitors that may constitute effective therapies, real-time in situ atomic force microscopy has been used to investigate the surface micromorphology and growth kinetics of the {0001} faces of L-cystine at various supersaturations and concentrations of the growth inhibitor L-cystine dimethylester (CDME). Crystal growth is actuated by screw dislocations on the {0001} L-cystine surface, producing hexagonal spiral hillocks that are a consequence of six interlacing spirals of anisotropic molecular layers. The high level of elastic stress in the immediate vicinity around the dislocation line results in a decrease in the step velocities and a corresponding increase in the spacing of steps. The kinetic curves acquired in the presence of CDME conform to the classical Cabrera–Vermilyea model. Anomalous birefringence in the {101̅0} growth sectors, combined with computational modeling, supports a high fidelity of stereospecific binding of CDME, in a unique orientation, exclusively at one of the six crystallographically unique projections on the {1010} plane. 2015 Journal Article http://hdl.handle.net/20.500.11937/33037 10.1021/cg501485e http://purl.org/au-research/grants/arc/DP140101776 American Chemical Society fulltext |
| spellingShingle | kidney stone formation - atomic force microscope - crystallization kinetics Shtukenberg, A. Poloni, L. Zhu, Z. An, Z. Bhandari, M. Song, P. Rohl, Andrew Kahr, B. Ward, M. Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level |
| title | Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level |
| title_full | Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level |
| title_fullStr | Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level |
| title_full_unstemmed | Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level |
| title_short | Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level |
| title_sort | dislocation-actuated growth and inhibition of hexagonal l-cystine crystallization at the molecular level |
| topic | kidney stone formation - atomic force microscope - crystallization kinetics |
| url | http://purl.org/au-research/grants/arc/DP140101776 http://hdl.handle.net/20.500.11937/33037 |