Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases

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Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases

Although statins are known to inhibit proliferation and induce death in a number of cancer cell types, the mechanisms through which downregulation of the mevalonate (MVA) pathway activates death signaling remain poorly understood. Here we set out to unravel the signaling networks downstream of the M...

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Bibliographic Details
Main Authors:	Zhu, Y., Casey, P., Kumar, Alan Prem, Pervaiz, S.
Format:	Journal Article
Published:	Nature Publishing Group 2013
Subjects:	Rho JNK superoxide apoptosis simvastatin
Online Access:	http://hdl.handle.net/20.500.11937/33015

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