Regulatory principles in metabolism -Then and now
The importance of metabolic pathways for life and the nature of participating reactions have challenged physiologists and biochemists for over a hundred years. Eric Arthur Newsholme contributed many original hypotheses and concepts to the field of metabolic regulation, demonstrating that metabolic p...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
Portland Press Ltd.
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/3286 |
| _version_ | 1848744189934698496 |
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| author | Curi, R. Newsholme, P. Marzuca-Nassr, G. Takahashi, H. Hirabara, S. Cruzat, Vinicius Krause, M. De Bittencourt, P. |
| author_facet | Curi, R. Newsholme, P. Marzuca-Nassr, G. Takahashi, H. Hirabara, S. Cruzat, Vinicius Krause, M. De Bittencourt, P. |
| author_sort | Curi, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The importance of metabolic pathways for life and the nature of participating reactions have challenged physiologists and biochemists for over a hundred years. Eric Arthur Newsholme contributed many original hypotheses and concepts to the field of metabolic regulation, demonstrating that metabolic pathways have a fundamental thermodynamic structure and that near identical regulatory mechanisms exist in multiple species across the animal kingdom. His work at Oxford University from the 1970s to 1990s was groundbreaking and led to better understanding of development and demise across the lifespan as well as the basis of metabolic disruption responsible for the development of obesity, diabetes and many other conditions. In the present review we describe some of the original work of Eric Newsholme, its relevance to metabolic homoeostasis and disease and application to present state-of-The-Art studies, which generate substantial amounts of data that are extremely difficult to interpret without a fundamental understanding of regulatory principles. Eric's work is a classical example of how one can unravel very complex problems by considering regulation from a cell, tissue and whole body perspective, thus bringing together metabolic biochemistry, physiology and pathophysiology, opening new avenues that now drive discovery decades thereafter. |
| first_indexed | 2025-11-14T05:57:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-3286 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T05:57:31Z |
| publishDate | 2016 |
| publisher | Portland Press Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-32862017-09-13T14:43:28Z Regulatory principles in metabolism -Then and now Curi, R. Newsholme, P. Marzuca-Nassr, G. Takahashi, H. Hirabara, S. Cruzat, Vinicius Krause, M. De Bittencourt, P. The importance of metabolic pathways for life and the nature of participating reactions have challenged physiologists and biochemists for over a hundred years. Eric Arthur Newsholme contributed many original hypotheses and concepts to the field of metabolic regulation, demonstrating that metabolic pathways have a fundamental thermodynamic structure and that near identical regulatory mechanisms exist in multiple species across the animal kingdom. His work at Oxford University from the 1970s to 1990s was groundbreaking and led to better understanding of development and demise across the lifespan as well as the basis of metabolic disruption responsible for the development of obesity, diabetes and many other conditions. In the present review we describe some of the original work of Eric Newsholme, its relevance to metabolic homoeostasis and disease and application to present state-of-The-Art studies, which generate substantial amounts of data that are extremely difficult to interpret without a fundamental understanding of regulatory principles. Eric's work is a classical example of how one can unravel very complex problems by considering regulation from a cell, tissue and whole body perspective, thus bringing together metabolic biochemistry, physiology and pathophysiology, opening new avenues that now drive discovery decades thereafter. 2016 Journal Article http://hdl.handle.net/20.500.11937/3286 10.1042/BCJ20160103 Portland Press Ltd. restricted |
| spellingShingle | Curi, R. Newsholme, P. Marzuca-Nassr, G. Takahashi, H. Hirabara, S. Cruzat, Vinicius Krause, M. De Bittencourt, P. Regulatory principles in metabolism -Then and now |
| title | Regulatory principles in metabolism -Then and now |
| title_full | Regulatory principles in metabolism -Then and now |
| title_fullStr | Regulatory principles in metabolism -Then and now |
| title_full_unstemmed | Regulatory principles in metabolism -Then and now |
| title_short | Regulatory principles in metabolism -Then and now |
| title_sort | regulatory principles in metabolism -then and now |
| url | http://hdl.handle.net/20.500.11937/3286 |