Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging.
Optical epifluorescence microscopy was used in conjunction with X-ray fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO)3(phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells. The rhen...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal Article |
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2016
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| Online Access: | http://purl.org/au-research/grants/arc/FT130100033 http://hdl.handle.net/20.500.11937/32821 |
| _version_ | 1848753770171727872 |
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| author | Wedding, J. Harris, H. Bader, C. Plush, S. Mak, R. Massi, M. Brooks, D. Lai, B. Vogt, S. Werrett, M. Simpson, Peter Skelton, B. Stagni, S. |
| author_facet | Wedding, J. Harris, H. Bader, C. Plush, S. Mak, R. Massi, M. Brooks, D. Lai, B. Vogt, S. Werrett, M. Simpson, Peter Skelton, B. Stagni, S. |
| author_sort | Wedding, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Optical epifluorescence microscopy was used in conjunction with X-ray fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO)3(phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells. The rhenium complex showed no signs of ancillary ligand dissociation, a conclusion based on data obtained via X-ray fluorescence imaging aligning iodine and rhenium distributions. A diffuse reticular localisation was detected for the complex in the nuclear/perinuclear region of cells, by either optical or X-ray fluorescence imaging techniques. X-ray fluorescence also showed that the rhenium complex disrupted the homeostasis of some biologically relevant elements, such as chlorine, potassium and zinc. |
| first_indexed | 2025-11-14T08:29:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-32821 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:29:47Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-328212023-01-25T06:56:16Z Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging. Wedding, J. Harris, H. Bader, C. Plush, S. Mak, R. Massi, M. Brooks, D. Lai, B. Vogt, S. Werrett, M. Simpson, Peter Skelton, B. Stagni, S. Optical epifluorescence microscopy was used in conjunction with X-ray fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO)3(phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells. The rhenium complex showed no signs of ancillary ligand dissociation, a conclusion based on data obtained via X-ray fluorescence imaging aligning iodine and rhenium distributions. A diffuse reticular localisation was detected for the complex in the nuclear/perinuclear region of cells, by either optical or X-ray fluorescence imaging techniques. X-ray fluorescence also showed that the rhenium complex disrupted the homeostasis of some biologically relevant elements, such as chlorine, potassium and zinc. 2016 Journal Article http://hdl.handle.net/20.500.11937/32821 10.1039/c6mt00243a http://purl.org/au-research/grants/arc/FT130100033 restricted |
| spellingShingle | Wedding, J. Harris, H. Bader, C. Plush, S. Mak, R. Massi, M. Brooks, D. Lai, B. Vogt, S. Werrett, M. Simpson, Peter Skelton, B. Stagni, S. Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging. |
| title | Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging. |
| title_full | Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging. |
| title_fullStr | Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging. |
| title_full_unstemmed | Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging. |
| title_short | Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging. |
| title_sort | intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with x-ray fluorescence imaging. |
| url | http://purl.org/au-research/grants/arc/FT130100033 http://hdl.handle.net/20.500.11937/32821 |