Molecular delivery of plasmids for genetic vaccination
Plasmid vaccination is a smart gene delivery application mostly achieved through the utilisation of viral or copolymeric systems as surrogated carriers in micro or nano formulations. A common polymeric protocol for plasmid vaccine formulation, which as somewhat been successful, is via the complexati...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/32660 |
| _version_ | 1848753724864856064 |
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| author | Mazid, R. Tan, M. Danquah, Michael |
| author_facet | Mazid, R. Tan, M. Danquah, Michael |
| author_sort | Mazid, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Plasmid vaccination is a smart gene delivery application mostly achieved through the utilisation of viral or copolymeric systems as surrogated carriers in micro or nano formulations. A common polymeric protocol for plasmid vaccine formulation, which as somewhat been successful, is via the complexation of the DNA molecules with a cationic polymer, and encapsulating in a vehicular carrier polymer. Even though plasmid vaccination research has not witnessed the much anticipated success, due a number of cellular and physicochemical reasons, application of copolymeric carriers with tight functionalities is a promising strategy to optimally deliver the DNA molecules; in view of the available chemistries and physical properties that could be tuned to enable enhanced targeted delivery, uptake and specific transfection. This also enables the targeting of specific epitopes and antigen presenting cells for the treatment of many pathogenic infections and cancer. This paper provides a brief critical review of the current state of plasmid vaccines formulation and molecular delivery with analysis of performance data obtained from clinical trials. |
| first_indexed | 2025-11-14T08:29:04Z |
| format | Journal Article |
| id | curtin-20.500.11937-32660 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:29:04Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-326602017-01-30T13:32:17Z Molecular delivery of plasmids for genetic vaccination Mazid, R. Tan, M. Danquah, Michael Plasmid vaccination is a smart gene delivery application mostly achieved through the utilisation of viral or copolymeric systems as surrogated carriers in micro or nano formulations. A common polymeric protocol for plasmid vaccine formulation, which as somewhat been successful, is via the complexation of the DNA molecules with a cationic polymer, and encapsulating in a vehicular carrier polymer. Even though plasmid vaccination research has not witnessed the much anticipated success, due a number of cellular and physicochemical reasons, application of copolymeric carriers with tight functionalities is a promising strategy to optimally deliver the DNA molecules; in view of the available chemistries and physical properties that could be tuned to enable enhanced targeted delivery, uptake and specific transfection. This also enables the targeting of specific epitopes and antigen presenting cells for the treatment of many pathogenic infections and cancer. This paper provides a brief critical review of the current state of plasmid vaccines formulation and molecular delivery with analysis of performance data obtained from clinical trials. 2013 Journal Article http://hdl.handle.net/20.500.11937/32660 restricted |
| spellingShingle | Mazid, R. Tan, M. Danquah, Michael Molecular delivery of plasmids for genetic vaccination |
| title | Molecular delivery of plasmids for genetic vaccination |
| title_full | Molecular delivery of plasmids for genetic vaccination |
| title_fullStr | Molecular delivery of plasmids for genetic vaccination |
| title_full_unstemmed | Molecular delivery of plasmids for genetic vaccination |
| title_short | Molecular delivery of plasmids for genetic vaccination |
| title_sort | molecular delivery of plasmids for genetic vaccination |
| url | http://hdl.handle.net/20.500.11937/32660 |