Short-interval intracortical inhibition and manual dexterity in healthy aging
Short-interval intracortical inhibition (SICI) acting on the first dorsal interosseus was measured usingpaired-pulse transcranial magnetic stimulation (interstimulus interval = 2 ms) in samples of young andhealthy older subjects and correlated with manual dexterity measured with the Purdue Pegboard...
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| Format: | Journal Article |
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Elsevier
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/32362 |
| _version_ | 1848753642705780736 |
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| author | Marneweck, M. Loftus, Andrea Hammond, G. |
| author_facet | Marneweck, M. Loftus, Andrea Hammond, G. |
| author_sort | Marneweck, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Short-interval intracortical inhibition (SICI) acting on the first dorsal interosseus was measured usingpaired-pulse transcranial magnetic stimulation (interstimulus interval = 2 ms) in samples of young andhealthy older subjects and correlated with manual dexterity measured with the Purdue Pegboard testand two isometric force-matching tasks. There was an age-related decrease in SICI and an age-relateddecline in all dexterity measures. The level of SICI was not correlated with any of the dexterity measures, but the appearance of atypical facilitation (rather than inhibition) in some subjects was associated with impaired pegboard performance but not force-matching performance. We conclude that SICI at rest is reduced with healthy aging but this loss of SICI does not directly contribute to the loss of dexterity; a shift in the balance of facilitatory and inhibitory processes in motor cortex to facilitation might interfere with sequenced hand movements. |
| first_indexed | 2025-11-14T08:27:46Z |
| format | Journal Article |
| id | curtin-20.500.11937-32362 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:27:46Z |
| publishDate | 2011 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-323622017-09-13T15:24:21Z Short-interval intracortical inhibition and manual dexterity in healthy aging Marneweck, M. Loftus, Andrea Hammond, G. Manual dexterity Aging SICI TMS Motor control Short-interval intracortical inhibition (SICI) acting on the first dorsal interosseus was measured usingpaired-pulse transcranial magnetic stimulation (interstimulus interval = 2 ms) in samples of young andhealthy older subjects and correlated with manual dexterity measured with the Purdue Pegboard testand two isometric force-matching tasks. There was an age-related decrease in SICI and an age-relateddecline in all dexterity measures. The level of SICI was not correlated with any of the dexterity measures, but the appearance of atypical facilitation (rather than inhibition) in some subjects was associated with impaired pegboard performance but not force-matching performance. We conclude that SICI at rest is reduced with healthy aging but this loss of SICI does not directly contribute to the loss of dexterity; a shift in the balance of facilitatory and inhibitory processes in motor cortex to facilitation might interfere with sequenced hand movements. 2011 Journal Article http://hdl.handle.net/20.500.11937/32362 10.1016/j.neures.2011.04.004 Elsevier restricted |
| spellingShingle | Manual dexterity Aging SICI TMS Motor control Marneweck, M. Loftus, Andrea Hammond, G. Short-interval intracortical inhibition and manual dexterity in healthy aging |
| title | Short-interval intracortical inhibition and manual dexterity in healthy aging |
| title_full | Short-interval intracortical inhibition and manual dexterity in healthy aging |
| title_fullStr | Short-interval intracortical inhibition and manual dexterity in healthy aging |
| title_full_unstemmed | Short-interval intracortical inhibition and manual dexterity in healthy aging |
| title_short | Short-interval intracortical inhibition and manual dexterity in healthy aging |
| title_sort | short-interval intracortical inhibition and manual dexterity in healthy aging |
| topic | Manual dexterity Aging SICI TMS Motor control |
| url | http://hdl.handle.net/20.500.11937/32362 |