Ancient human genome sequence of an extinct Palaeo-Eskimo

We report here the genome sequence of an ancient human. Obtained from,4,000-year-old permafrost-preserved hair, thegenome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of203, we recover 79% of the diploid genome, an amount close to th...

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Main Authors:	Rasmussen, M., Li, Y., Lindgreen, S., Pedersen, J., Albrechtsen, A., Metspalu, M., Metspalu, E., Kivisild, T., Gupta, R., Bertalan, M., Nielsen, K., Gilbert, Thomas, Wang, Y., Raghavan, M., Campos, P., Kamp, H., Wilson, A., Gledhill, A., Tridico, S., Bunce, Michael, Lorenzen, E., Binladen, J., Guo, X., Zhao, J., Zhang, X., Zhang, H., Li, Z., Chen, M., Orlando, L., Kristiansen, K., Bak, M., Tommerup, N., Bendixen, C., Pierre, T., Grønnow, B., Meldgaard, M., Andreasen, C., Fedorova, S., Osipova, L., Higham, T., Ramsey, C., Hansen, T., Nielsen, F., Crawford, M., Brunak, S., Sicheritz-Ponten, T., Villems, R., Nielsen, R., Krogh, A., Wang, Jun, Willerslev, E., Moltke, I.
Format:	Journal Article
Published:	Nature Publishing Group 2010
Online Access:	http://hdl.handle.net/20.500.11937/31802

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author	Rasmussen, M. Li, Y. Lindgreen, S. Pedersen, J. Albrechtsen, A. Metspalu, M. Metspalu, E. Kivisild, T. Gupta, R. Bertalan, M. Nielsen, K. Gilbert, Thomas Wang, Y. Raghavan, M. Campos, P. Kamp, H. Wilson, A. Gledhill, A. Tridico, S. Bunce, Michael Lorenzen, E. Binladen, J. Guo, X. Zhao, J. Zhang, X. Zhang, H. Li, Z. Chen, M. Orlando, L. Kristiansen, K. Bak, M. Tommerup, N. Bendixen, C. Pierre, T. Grønnow, B. Meldgaard, M. Andreasen, C. Fedorova, S. Osipova, L. Higham, T. Ramsey, C. Hansen, T. Nielsen, F. Crawford, M. Brunak, S. Sicheritz-Ponten, T. Villems, R. Nielsen, R. Krogh, A. Wang, Jun Willerslev, E. Moltke, I.
author_facet	Rasmussen, M. Li, Y. Lindgreen, S. Pedersen, J. Albrechtsen, A. Metspalu, M. Metspalu, E. Kivisild, T. Gupta, R. Bertalan, M. Nielsen, K. Gilbert, Thomas Wang, Y. Raghavan, M. Campos, P. Kamp, H. Wilson, A. Gledhill, A. Tridico, S. Bunce, Michael Lorenzen, E. Binladen, J. Guo, X. Zhao, J. Zhang, X. Zhang, H. Li, Z. Chen, M. Orlando, L. Kristiansen, K. Bak, M. Tommerup, N. Bendixen, C. Pierre, T. Grønnow, B. Meldgaard, M. Andreasen, C. Fedorova, S. Osipova, L. Higham, T. Ramsey, C. Hansen, T. Nielsen, F. Crawford, M. Brunak, S. Sicheritz-Ponten, T. Villems, R. Nielsen, R. Krogh, A. Wang, Jun Willerslev, E. Moltke, I.
author_sort	Rasmussen, M.
building	Curtin Institutional Repository
collection	Online Access
description	We report here the genome sequence of an ancient human. Obtained from,4,000-year-old permafrost-preserved hair, thegenome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of203, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. Weidentify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reportedpreviously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assignpossible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace humanremains.We compare the high-confidence SNPs to those of contemporary populations to find the populations most closelyrelated to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago,independent of that giving rise to the modern Native Americans and Inuit.
first_indexed	2025-11-14T08:25:15Z
format	Journal Article
id	curtin-20.500.11937-31802
institution	Curtin University Malaysia
institution_category	Local University
last_indexed	2025-11-14T08:25:15Z
publishDate	2010
publisher	Nature Publishing Group
recordtype	eprints
repository_type	Digital Repository
spelling	curtin-20.500.11937-318022017-09-13T15:20:01Z Ancient human genome sequence of an extinct Palaeo-Eskimo Rasmussen, M. Li, Y. Lindgreen, S. Pedersen, J. Albrechtsen, A. Metspalu, M. Metspalu, E. Kivisild, T. Gupta, R. Bertalan, M. Nielsen, K. Gilbert, Thomas Wang, Y. Raghavan, M. Campos, P. Kamp, H. Wilson, A. Gledhill, A. Tridico, S. Bunce, Michael Lorenzen, E. Binladen, J. Guo, X. Zhao, J. Zhang, X. Zhang, H. Li, Z. Chen, M. Orlando, L. Kristiansen, K. Bak, M. Tommerup, N. Bendixen, C. Pierre, T. Grønnow, B. Meldgaard, M. Andreasen, C. Fedorova, S. Osipova, L. Higham, T. Ramsey, C. Hansen, T. Nielsen, F. Crawford, M. Brunak, S. Sicheritz-Ponten, T. Villems, R. Nielsen, R. Krogh, A. Wang, Jun Willerslev, E. Moltke, I. We report here the genome sequence of an ancient human. Obtained from,4,000-year-old permafrost-preserved hair, thegenome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of203, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. Weidentify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reportedpreviously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assignpossible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace humanremains.We compare the high-confidence SNPs to those of contemporary populations to find the populations most closelyrelated to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago,independent of that giving rise to the modern Native Americans and Inuit. 2010 Journal Article http://hdl.handle.net/20.500.11937/31802 10.1038/nature08835 Nature Publishing Group unknown
spellingShingle	Rasmussen, M. Li, Y. Lindgreen, S. Pedersen, J. Albrechtsen, A. Metspalu, M. Metspalu, E. Kivisild, T. Gupta, R. Bertalan, M. Nielsen, K. Gilbert, Thomas Wang, Y. Raghavan, M. Campos, P. Kamp, H. Wilson, A. Gledhill, A. Tridico, S. Bunce, Michael Lorenzen, E. Binladen, J. Guo, X. Zhao, J. Zhang, X. Zhang, H. Li, Z. Chen, M. Orlando, L. Kristiansen, K. Bak, M. Tommerup, N. Bendixen, C. Pierre, T. Grønnow, B. Meldgaard, M. Andreasen, C. Fedorova, S. Osipova, L. Higham, T. Ramsey, C. Hansen, T. Nielsen, F. Crawford, M. Brunak, S. Sicheritz-Ponten, T. Villems, R. Nielsen, R. Krogh, A. Wang, Jun Willerslev, E. Moltke, I. Ancient human genome sequence of an extinct Palaeo-Eskimo
title	Ancient human genome sequence of an extinct Palaeo-Eskimo
title_full	Ancient human genome sequence of an extinct Palaeo-Eskimo
title_fullStr	Ancient human genome sequence of an extinct Palaeo-Eskimo
title_full_unstemmed	Ancient human genome sequence of an extinct Palaeo-Eskimo
title_short	Ancient human genome sequence of an extinct Palaeo-Eskimo
title_sort	ancient human genome sequence of an extinct palaeo-eskimo
url	http://hdl.handle.net/20.500.11937/31802

Ancient human genome sequence of an extinct Palaeo-Eskimo

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