Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey
The emergence of carbapenem resistance in Pseudomonas aeruginosa threatens the efficacy of this important anti-pseudomonal antibiotic class. Between 2003 and 2006, an increase in the number of carbapenem-resistant P. aeruginosa isolates at the Zonguldak Karaelmas University Hospital was observed (Zo...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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Blackwell Publishing
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/31735 |
| _version_ | 1848753465075957760 |
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| author | Mac Aogáin, M. Kulah, C. Rijnsburger, M. Celebi, G. Savelkoul, P. O'Gara, Fergal Mooij, M. |
| author_facet | Mac Aogáin, M. Kulah, C. Rijnsburger, M. Celebi, G. Savelkoul, P. O'Gara, Fergal Mooij, M. |
| author_sort | Mac Aogáin, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The emergence of carbapenem resistance in Pseudomonas aeruginosa threatens the efficacy of this important anti-pseudomonal antibiotic class. Between 2003 and 2006, an increase in the number of carbapenem-resistant P. aeruginosa isolates at the Zonguldak Karaelmas University Hospital was observed (Zongul-dak, Turkey). To assess the imipenem resistance mechanisms emerging in these P. aeruginosa isolates, they were characterized by amplified fragment length polymorphism typing, which revealed diversity among imipenem-resistant isolates as well as two clonally related outbreak groups. The molecular mechanism of carbapenem resistance was characterized in a representative isolate from each clonal group. Mutational disruption of oprD was the most frequently encountered resistance mechanism (23/27 isolates). |
| first_indexed | 2025-11-14T08:24:56Z |
| format | Journal Article |
| id | curtin-20.500.11937-31735 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:24:56Z |
| publishDate | 2012 |
| publisher | Blackwell Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-317352017-09-13T15:20:31Z Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey Mac Aogáin, M. Kulah, C. Rijnsburger, M. Celebi, G. Savelkoul, P. O'Gara, Fergal Mooij, M. The emergence of carbapenem resistance in Pseudomonas aeruginosa threatens the efficacy of this important anti-pseudomonal antibiotic class. Between 2003 and 2006, an increase in the number of carbapenem-resistant P. aeruginosa isolates at the Zonguldak Karaelmas University Hospital was observed (Zongul-dak, Turkey). To assess the imipenem resistance mechanisms emerging in these P. aeruginosa isolates, they were characterized by amplified fragment length polymorphism typing, which revealed diversity among imipenem-resistant isolates as well as two clonally related outbreak groups. The molecular mechanism of carbapenem resistance was characterized in a representative isolate from each clonal group. Mutational disruption of oprD was the most frequently encountered resistance mechanism (23/27 isolates). 2012 Journal Article http://hdl.handle.net/20.500.11937/31735 10.1111/j.1469-0691.2012.03899.x Blackwell Publishing unknown |
| spellingShingle | Mac Aogáin, M. Kulah, C. Rijnsburger, M. Celebi, G. Savelkoul, P. O'Gara, Fergal Mooij, M. Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey |
| title | Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey |
| title_full | Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey |
| title_fullStr | Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey |
| title_full_unstemmed | Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey |
| title_short | Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey |
| title_sort | characterization of imipenem resistance mechanisms in pseudomonas aeruginosa isolates from turkey |
| url | http://hdl.handle.net/20.500.11937/31735 |