Cerebral CT angiography and CT perfusion in acute stroke detection: a systematic review of diagnostic value
The purpose of this study was to analyse the diagnostic value of cerebral CT angiography (CTA) and CT perfusion (CTP) examinations in the detection of acute stroke based on a systematic review of the current literature. The review was conducted based on searching of seven databases for articles publ...
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| Format: | Journal Article |
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AME Publishing Company
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/3170 |
| _version_ | 1848744158172282880 |
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| author | Sabarudin, Akmal Subramaniam, C. Sun, Zhonghua |
| author_facet | Sabarudin, Akmal Subramaniam, C. Sun, Zhonghua |
| author_sort | Sabarudin, Akmal |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The purpose of this study was to analyse the diagnostic value of cerebral CT angiography (CTA) and CT perfusion (CTP) examinations in the detection of acute stroke based on a systematic review of the current literature. The review was conducted based on searching of seven databases for articles published between 1993 and 2013. Diagnostic value in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy was analysed from 21 articles which were found to meet selection criteria. The mean sensitivity, specificity, PPV, NPV and accuracy for CTA were significantly higher than those for CTP with 83.2% (95% CI: 57.9-100.0%), 95.0% (95% CI: 74.4-100%), 84.1% (95% CI: 50.0-100%), 97.1 (95% CI: 94.0-100%) and 94.0% (95% CI: 83.0-99.0) versus 69.9% (95% CI: 20.0-97.0%), 87.4 (95% CI: 61.0-100.0%), 76.4% (95% CI: 48.0-95.4%), 78.2% (95% CI: 55.8-93.9%) and 89.8% (95% CI: 75.7-97.1%), respectively. This analysis shows that CTA has high diagnostic value in detecting high degree of cerebral arterial stenosis (>70%) whereas CTP provides high specificity in the detection of ischemia and infarct tissue of brain. |
| first_indexed | 2025-11-14T05:57:01Z |
| format | Journal Article |
| id | curtin-20.500.11937-3170 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T05:57:01Z |
| publishDate | 2014 |
| publisher | AME Publishing Company |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-31702017-09-13T14:31:36Z Cerebral CT angiography and CT perfusion in acute stroke detection: a systematic review of diagnostic value Sabarudin, Akmal Subramaniam, C. Sun, Zhonghua diagnostic accuracy Cerebral CT angiography CT perfusion (CTP) acute stroke The purpose of this study was to analyse the diagnostic value of cerebral CT angiography (CTA) and CT perfusion (CTP) examinations in the detection of acute stroke based on a systematic review of the current literature. The review was conducted based on searching of seven databases for articles published between 1993 and 2013. Diagnostic value in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy was analysed from 21 articles which were found to meet selection criteria. The mean sensitivity, specificity, PPV, NPV and accuracy for CTA were significantly higher than those for CTP with 83.2% (95% CI: 57.9-100.0%), 95.0% (95% CI: 74.4-100%), 84.1% (95% CI: 50.0-100%), 97.1 (95% CI: 94.0-100%) and 94.0% (95% CI: 83.0-99.0) versus 69.9% (95% CI: 20.0-97.0%), 87.4 (95% CI: 61.0-100.0%), 76.4% (95% CI: 48.0-95.4%), 78.2% (95% CI: 55.8-93.9%) and 89.8% (95% CI: 75.7-97.1%), respectively. This analysis shows that CTA has high diagnostic value in detecting high degree of cerebral arterial stenosis (>70%) whereas CTP provides high specificity in the detection of ischemia and infarct tissue of brain. 2014 Journal Article http://hdl.handle.net/20.500.11937/3170 10.3978/j.issn.2223-4292.2014.07.10 AME Publishing Company fulltext |
| spellingShingle | diagnostic accuracy Cerebral CT angiography CT perfusion (CTP) acute stroke Sabarudin, Akmal Subramaniam, C. Sun, Zhonghua Cerebral CT angiography and CT perfusion in acute stroke detection: a systematic review of diagnostic value |
| title | Cerebral CT angiography and CT perfusion in acute stroke detection: a systematic review of diagnostic value |
| title_full | Cerebral CT angiography and CT perfusion in acute stroke detection: a systematic review of diagnostic value |
| title_fullStr | Cerebral CT angiography and CT perfusion in acute stroke detection: a systematic review of diagnostic value |
| title_full_unstemmed | Cerebral CT angiography and CT perfusion in acute stroke detection: a systematic review of diagnostic value |
| title_short | Cerebral CT angiography and CT perfusion in acute stroke detection: a systematic review of diagnostic value |
| title_sort | cerebral ct angiography and ct perfusion in acute stroke detection: a systematic review of diagnostic value |
| topic | diagnostic accuracy Cerebral CT angiography CT perfusion (CTP) acute stroke |
| url | http://hdl.handle.net/20.500.11937/3170 |