Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status
The ε4 polymorphism of the APOE gene confers a substantially increased risk of developing Alzheimer's disease (AD). However, the influence of the ε4 allele on cognitive functioning in ageing individuals is more contentious. Previously, we demonstrated relatively little evidence for a role of th...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier
2014
|
| Online Access: | http://hdl.handle.net/20.500.11937/3155 |
| _version_ | 1848744153964347392 |
|---|---|
| author | Foster, J. Albrecht, Matthew Szoeke, C. Maruff, P. Savage, G. Lautenschlager, N. Ellis, K. Taddei, K. Martins, R. Masters, C. Ames, D. |
| author_facet | Foster, J. Albrecht, Matthew Szoeke, C. Maruff, P. Savage, G. Lautenschlager, N. Ellis, K. Taddei, K. Martins, R. Masters, C. Ames, D. |
| author_sort | Foster, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The ε4 polymorphism of the APOE gene confers a substantially increased risk of developing Alzheimer's disease (AD). However, the influence of the ε4 allele on cognitive functioning in ageing individuals is more contentious. Previously, we demonstrated relatively little evidence for a role of the ε4 allele on baseline cognitive performance in older adults in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing (Foster et al [2013], BRAIN, 136, 2201-16). We here investigated whether the APOE ε4 allele influenced cognitive status over time when the AIBL cohort was followed longitudinally over a 3-year period. |
| first_indexed | 2025-11-14T05:56:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-3155 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T05:56:57Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-31552017-09-13T14:33:01Z Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status Foster, J. Albrecht, Matthew Szoeke, C. Maruff, P. Savage, G. Lautenschlager, N. Ellis, K. Taddei, K. Martins, R. Masters, C. Ames, D. The ε4 polymorphism of the APOE gene confers a substantially increased risk of developing Alzheimer's disease (AD). However, the influence of the ε4 allele on cognitive functioning in ageing individuals is more contentious. Previously, we demonstrated relatively little evidence for a role of the ε4 allele on baseline cognitive performance in older adults in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing (Foster et al [2013], BRAIN, 136, 2201-16). We here investigated whether the APOE ε4 allele influenced cognitive status over time when the AIBL cohort was followed longitudinally over a 3-year period. 2014 Journal Article http://hdl.handle.net/20.500.11937/3155 10.1016/j.jalz.2014.04.303 Elsevier restricted |
| spellingShingle | Foster, J. Albrecht, Matthew Szoeke, C. Maruff, P. Savage, G. Lautenschlager, N. Ellis, K. Taddei, K. Martins, R. Masters, C. Ames, D. Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status |
| title | Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status |
| title_full | Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status |
| title_fullStr | Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status |
| title_full_unstemmed | Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status |
| title_short | Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status |
| title_sort | longitudinal cognitive decline in the aibl cohort: the role of apoe ε4 status |
| url | http://hdl.handle.net/20.500.11937/3155 |