Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women
Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2016
|
| Online Access: | http://hdl.handle.net/20.500.11937/31411 |
| _version_ | 1848753373468164096 |
|---|---|
| author | Lee, Andy Tan, L. Hiramatsu, N. Ishisaka, A. Alfonso, Helman Tanaka, A. Uemura, N. Fujiwara, Y. Takechi, Ryu |
| author_facet | Lee, Andy Tan, L. Hiramatsu, N. Ishisaka, A. Alfonso, Helman Tanaka, A. Uemura, N. Fujiwara, Y. Takechi, Ryu |
| author_sort | Lee, Andy |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffee polyphenols and diabetic risks has never been investigated in the literature. In this study, fasting plasma samples were collected from 57 generally healthy females aged 38-73 (mean 52, s.d. 8) years recruited in Himeji, Japan. The concentrations of plasma coffee polyphenols were determined by liquid chromatography coupled with mass tandem spectrometer. Diabetes biomarkers in the plasma/serum samples were analysed by a commercial diagnostic laboratory. Statistical associations were assessed using Spearman's correlation coefficients. The results showed that plasma chlorogenic acid exhibited negative associations with fasting blood glucose, glycated hemoglobin and C-reactive protein, whereas plasma total coffee polyphenol and plasma caffeic acid were weakly associated with these biomarkers. Our preliminary data support previous findings that coffee polyphenols have anti-diabetic effects but further replications with large samples of both genders are recommended. |
| first_indexed | 2025-11-14T08:23:29Z |
| format | Journal Article |
| id | curtin-20.500.11937-31411 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:23:29Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-314112017-09-13T15:20:00Z Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women Lee, Andy Tan, L. Hiramatsu, N. Ishisaka, A. Alfonso, Helman Tanaka, A. Uemura, N. Fujiwara, Y. Takechi, Ryu Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffee polyphenols and diabetic risks has never been investigated in the literature. In this study, fasting plasma samples were collected from 57 generally healthy females aged 38-73 (mean 52, s.d. 8) years recruited in Himeji, Japan. The concentrations of plasma coffee polyphenols were determined by liquid chromatography coupled with mass tandem spectrometer. Diabetes biomarkers in the plasma/serum samples were analysed by a commercial diagnostic laboratory. Statistical associations were assessed using Spearman's correlation coefficients. The results showed that plasma chlorogenic acid exhibited negative associations with fasting blood glucose, glycated hemoglobin and C-reactive protein, whereas plasma total coffee polyphenol and plasma caffeic acid were weakly associated with these biomarkers. Our preliminary data support previous findings that coffee polyphenols have anti-diabetic effects but further replications with large samples of both genders are recommended. 2016 Journal Article http://hdl.handle.net/20.500.11937/31411 10.1038/nutd.2016.19 fulltext |
| spellingShingle | Lee, Andy Tan, L. Hiramatsu, N. Ishisaka, A. Alfonso, Helman Tanaka, A. Uemura, N. Fujiwara, Y. Takechi, Ryu Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women |
| title | Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women |
| title_full | Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women |
| title_fullStr | Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women |
| title_full_unstemmed | Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women |
| title_short | Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women |
| title_sort | plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy japanese women |
| url | http://hdl.handle.net/20.500.11937/31411 |