An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

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An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

While CCR5 is the principal coreceptor used by macrophage (M)-tropic HIV-1, not all primary CCR5-using (R5) viruses enter macrophages efficiently. Here, we used functionally-diverse R5 envelope (Env) clones to characterize virus-cell interactions important for efficient CCR5-mediated macrophage entr...

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Bibliographic Details
Main Authors:	Sterjovski, J., Roche, M., Churchill, M., Ellett, A., Farrugia, W., Gray, L., Cowley, D., Poumbourios, P., Lee, B., Wesselingh, S., Cunningham, A., Ramsland, Paul, Gorry, P.
Format:	Journal Article
Published:	Reed Elsevier 2010
Online Access:	http://hdl.handle.net/20.500.11937/31354

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