Burn injury and long-term nervous system morbidity: A population-based cohort study
Objective To investigate if children and adults who are hospitalised for a burn injury have increased long-term hospital use for nervous system diseases. Design A population-based retrospective cohort study using linked administrative health data from the Western Australian Data Linkage System. Part...
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| Format: | Journal Article |
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BM J Group
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/31315 |
| _version_ | 1848753345012957184 |
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| author | Vetrichevvel, T. Randall, Sean Fear, M. Wood, F. Boyd, James Duke, J. |
| author_facet | Vetrichevvel, T. Randall, Sean Fear, M. Wood, F. Boyd, James Duke, J. |
| author_sort | Vetrichevvel, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective To investigate if children and adults who are hospitalised for a burn injury have increased long-term hospital use for nervous system diseases. Design A population-based retrospective cohort study using linked administrative health data from the Western Australian Data Linkage System. Participants Records of 30 997 persons hospitalised for a first burn injury in Western Australia during the period 1980–2012, and 123 399 persons who were age and gender frequency matched with no injury admissions randomly selected from Western Australia's birth registrations and electoral roll. Main outcome measures Admission rates and summed length of stay for nervous system diseases. Negative binomial and Cox proportional hazards regression modelling were used to generate incidence rate ratios (IRRs) and HRs with 95% CIs, respectively. Results After adjustment for demographic factors and pre-existing health status, the burn injury cohort had 2.20 times (95% CI 1.86 to 2.61) as many nervous system admissions and 3.25 times the number of days in hospital (95% CI: 2.28 to 4.64) than the uninjured cohort. This increase was found for those who had sustained burns during childhood (<15 years: IRR, 95% CI: 1.97, 1.49 to 2.61) and early to mid-adulthood (15–45 years: IRR, 95% CI: 2.70, 2.06 to 3.55) and older adults (≥45 years: IRR, 95% CI: 1.62, 1.33 to 1.97). Significantly elevated first-time postburn admissions were observed for children for 15 years postburn discharge (0–5 years: HR, 95% CI: 1.97, 1.75 to 2.22; 5–15 years: HR, 95% CI: 1.44, 1.28 to 1.63) and for adults 45 years and older at index burn for 5 years postburn only (HR, 95% CI: 1.72, 1.42 to 2.09). Conclusions Burn injury appears to be associated with increased nervous system-related morbidity for many years after burn injury. Further work into the mechanisms and possible treatments to reduce this morbidity are warranted in light of these findings. |
| first_indexed | 2025-11-14T08:23:02Z |
| format | Journal Article |
| id | curtin-20.500.11937-31315 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:23:02Z |
| publishDate | 2016 |
| publisher | BM J Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-313152017-09-13T15:19:34Z Burn injury and long-term nervous system morbidity: A population-based cohort study Vetrichevvel, T. Randall, Sean Fear, M. Wood, F. Boyd, James Duke, J. Objective To investigate if children and adults who are hospitalised for a burn injury have increased long-term hospital use for nervous system diseases. Design A population-based retrospective cohort study using linked administrative health data from the Western Australian Data Linkage System. Participants Records of 30 997 persons hospitalised for a first burn injury in Western Australia during the period 1980–2012, and 123 399 persons who were age and gender frequency matched with no injury admissions randomly selected from Western Australia's birth registrations and electoral roll. Main outcome measures Admission rates and summed length of stay for nervous system diseases. Negative binomial and Cox proportional hazards regression modelling were used to generate incidence rate ratios (IRRs) and HRs with 95% CIs, respectively. Results After adjustment for demographic factors and pre-existing health status, the burn injury cohort had 2.20 times (95% CI 1.86 to 2.61) as many nervous system admissions and 3.25 times the number of days in hospital (95% CI: 2.28 to 4.64) than the uninjured cohort. This increase was found for those who had sustained burns during childhood (<15 years: IRR, 95% CI: 1.97, 1.49 to 2.61) and early to mid-adulthood (15–45 years: IRR, 95% CI: 2.70, 2.06 to 3.55) and older adults (≥45 years: IRR, 95% CI: 1.62, 1.33 to 1.97). Significantly elevated first-time postburn admissions were observed for children for 15 years postburn discharge (0–5 years: HR, 95% CI: 1.97, 1.75 to 2.22; 5–15 years: HR, 95% CI: 1.44, 1.28 to 1.63) and for adults 45 years and older at index burn for 5 years postburn only (HR, 95% CI: 1.72, 1.42 to 2.09). Conclusions Burn injury appears to be associated with increased nervous system-related morbidity for many years after burn injury. Further work into the mechanisms and possible treatments to reduce this morbidity are warranted in light of these findings. 2016 Journal Article http://hdl.handle.net/20.500.11937/31315 10.1136/bmjopen-2016-012668 BM J Group unknown |
| spellingShingle | Vetrichevvel, T. Randall, Sean Fear, M. Wood, F. Boyd, James Duke, J. Burn injury and long-term nervous system morbidity: A population-based cohort study |
| title | Burn injury and long-term nervous system morbidity: A population-based cohort study |
| title_full | Burn injury and long-term nervous system morbidity: A population-based cohort study |
| title_fullStr | Burn injury and long-term nervous system morbidity: A population-based cohort study |
| title_full_unstemmed | Burn injury and long-term nervous system morbidity: A population-based cohort study |
| title_short | Burn injury and long-term nervous system morbidity: A population-based cohort study |
| title_sort | burn injury and long-term nervous system morbidity: a population-based cohort study |
| url | http://hdl.handle.net/20.500.11937/31315 |