Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids
Purpose: The purpose of this study was to evaluate the chemical stability of Lincocin® (lincomycin hydrochloride) in commonly used intravenous fluids at room temperature (25°C), at accelerated-degradation temperatures and in selected buffer solutions. Materials and methods: The stability of Lincocin...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Dove Medical Press Ltd.
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/31267 |
| _version_ | 1848753330416779264 |
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| author | Czarniak, Petra Boddy, M. Sunderland, Bruce Hughes, Jeff |
| author_facet | Czarniak, Petra Boddy, M. Sunderland, Bruce Hughes, Jeff |
| author_sort | Czarniak, Petra |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purpose: The purpose of this study was to evaluate the chemical stability of Lincocin® (lincomycin hydrochloride) in commonly used intravenous fluids at room temperature (25°C), at accelerated-degradation temperatures and in selected buffer solutions. Materials and methods: The stability of Lincocin® injection (containing lincomycin 600 mg/2 mL as the hydrochloride) stored at 25°C±0.1°C in sodium lactate (Hartmann’s), 0.9% sodium chloride, 5% glucose, and 10% glucose solutions was investigated over 31 days. Forced degradation of Lincocin® in hydrochloric acid, sodium hydroxide, and hydrogen peroxide was performed at 60°C. The effect of pH on the degradation rate of lincomycin hydrochloride stored at 80°C was determined. Results: Lincomycin hydrochloride was found to maintain its shelf life at 25°C in sodium lactate (Hartmann’s) solution, 0.9% sodium chloride solution, 5% glucose solution, and 10% glucose solution, with less than 5% lincomycin degradation occurring in all intravenous solutions over a 31-day period. Lincomycin hydrochloride showed less rapid degradation at 60°C in acid than in basic solution, but degraded rapidly in hydrogen peroxide. At all pH values tested, lincomycin followed first-order kinetics. It had the greatest stability near pH 4 when stored at 80°C (calculated shelf life of 4.59 days), and was least stable at pH 2 (calculated shelf life of 0.38 days). Conclusion: Lincocin® injection was chemically found to have a shelf life of at least 31 days at 25°C when added to sodium lactate (Hartmann’s) solution, 0.9% sodium chloride solution, 5% glucose solution, and 10% glucose solution. Solutions prepared at approximately pH 4 are likely to have optimum stability. |
| first_indexed | 2025-11-14T08:22:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-31267 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:22:48Z |
| publishDate | 2016 |
| publisher | Dove Medical Press Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-312672017-09-13T15:56:35Z Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids Czarniak, Petra Boddy, M. Sunderland, Bruce Hughes, Jeff Purpose: The purpose of this study was to evaluate the chemical stability of Lincocin® (lincomycin hydrochloride) in commonly used intravenous fluids at room temperature (25°C), at accelerated-degradation temperatures and in selected buffer solutions. Materials and methods: The stability of Lincocin® injection (containing lincomycin 600 mg/2 mL as the hydrochloride) stored at 25°C±0.1°C in sodium lactate (Hartmann’s), 0.9% sodium chloride, 5% glucose, and 10% glucose solutions was investigated over 31 days. Forced degradation of Lincocin® in hydrochloric acid, sodium hydroxide, and hydrogen peroxide was performed at 60°C. The effect of pH on the degradation rate of lincomycin hydrochloride stored at 80°C was determined. Results: Lincomycin hydrochloride was found to maintain its shelf life at 25°C in sodium lactate (Hartmann’s) solution, 0.9% sodium chloride solution, 5% glucose solution, and 10% glucose solution, with less than 5% lincomycin degradation occurring in all intravenous solutions over a 31-day period. Lincomycin hydrochloride showed less rapid degradation at 60°C in acid than in basic solution, but degraded rapidly in hydrogen peroxide. At all pH values tested, lincomycin followed first-order kinetics. It had the greatest stability near pH 4 when stored at 80°C (calculated shelf life of 4.59 days), and was least stable at pH 2 (calculated shelf life of 0.38 days). Conclusion: Lincocin® injection was chemically found to have a shelf life of at least 31 days at 25°C when added to sodium lactate (Hartmann’s) solution, 0.9% sodium chloride solution, 5% glucose solution, and 10% glucose solution. Solutions prepared at approximately pH 4 are likely to have optimum stability. 2016 Journal Article http://hdl.handle.net/20.500.11937/31267 10.2147/DDDT.S94710 Dove Medical Press Ltd. fulltext |
| spellingShingle | Czarniak, Petra Boddy, M. Sunderland, Bruce Hughes, Jeff Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids |
| title | Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids |
| title_full | Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids |
| title_fullStr | Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids |
| title_full_unstemmed | Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids |
| title_short | Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids |
| title_sort | stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids |
| url | http://hdl.handle.net/20.500.11937/31267 |