microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer
A large number of etiological factors and the complexity of breast cancers present challenges for prevention and treatment. Recently, the emergence of microRNAs (miRNAs) as cancer biomarkers has added an extra dimension to the ‘molecular signatures’ of breast cancer. Bioinformatic analyses indicate...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Blackwell Publishing Ltd
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/31197 |
| _version_ | 1848753310059724800 |
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| author | Goh, J. Loo, S. Datta, A. Siveen, K. Yap, W. Cai, W. Shin, E. Wang, C. Kim, J. Chan, M. Dharmarajan, Arunasalam Lee, A. Lobie, P. Yap, C. Kumar, A. |
| author_facet | Goh, J. Loo, S. Datta, A. Siveen, K. Yap, W. Cai, W. Shin, E. Wang, C. Kim, J. Chan, M. Dharmarajan, Arunasalam Lee, A. Lobie, P. Yap, C. Kumar, A. |
| author_sort | Goh, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A large number of etiological factors and the complexity of breast cancers present challenges for prevention and treatment. Recently, the emergence of microRNAs (miRNAs) as cancer biomarkers has added an extra dimension to the ‘molecular signatures’ of breast cancer. Bioinformatic analyses indicate that each miRNA can regulate hundreds of target genes and could serve functionally as ‘oncogenes’ or ‘tumour suppressor’ genes, and co-ordinate multiple cellular processes relevant to cancer progression. A number of studies have shown that miRNAs play important roles in breast tumorigenesis, metastasis, proliferation and differentiation of breast cancer cells. This review provides a comprehensive overview of miRNAs with established functional relevance in breast cancer, their established target genes and resulting cellular phenotype. The role and application of circulating miRNAs in breast cancer is also discussed. Furthermore, we summarize the role of miRNAs in the hallmarks of breast cancer, as well as the possibility of using miRNAs as potential biomarkers for detection of breast cancer. |
| first_indexed | 2025-11-14T08:22:29Z |
| format | Journal Article |
| id | curtin-20.500.11937-31197 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:22:29Z |
| publishDate | 2015 |
| publisher | Blackwell Publishing Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-311972017-09-13T15:11:56Z microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer Goh, J. Loo, S. Datta, A. Siveen, K. Yap, W. Cai, W. Shin, E. Wang, C. Kim, J. Chan, M. Dharmarajan, Arunasalam Lee, A. Lobie, P. Yap, C. Kumar, A. A large number of etiological factors and the complexity of breast cancers present challenges for prevention and treatment. Recently, the emergence of microRNAs (miRNAs) as cancer biomarkers has added an extra dimension to the ‘molecular signatures’ of breast cancer. Bioinformatic analyses indicate that each miRNA can regulate hundreds of target genes and could serve functionally as ‘oncogenes’ or ‘tumour suppressor’ genes, and co-ordinate multiple cellular processes relevant to cancer progression. A number of studies have shown that miRNAs play important roles in breast tumorigenesis, metastasis, proliferation and differentiation of breast cancer cells. This review provides a comprehensive overview of miRNAs with established functional relevance in breast cancer, their established target genes and resulting cellular phenotype. The role and application of circulating miRNAs in breast cancer is also discussed. Furthermore, we summarize the role of miRNAs in the hallmarks of breast cancer, as well as the possibility of using miRNAs as potential biomarkers for detection of breast cancer. 2015 Journal Article http://hdl.handle.net/20.500.11937/31197 10.1111/brv.12176 Blackwell Publishing Ltd restricted |
| spellingShingle | Goh, J. Loo, S. Datta, A. Siveen, K. Yap, W. Cai, W. Shin, E. Wang, C. Kim, J. Chan, M. Dharmarajan, Arunasalam Lee, A. Lobie, P. Yap, C. Kumar, A. microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer |
| title | microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer |
| title_full | microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer |
| title_fullStr | microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer |
| title_full_unstemmed | microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer |
| title_short | microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer |
| title_sort | micrornas in breast cancer: regulatory roles governing the hallmarks of cancer |
| url | http://hdl.handle.net/20.500.11937/31197 |