Electrochemically Modulated Liquid-Liquid Extraction of Ionized Drugs under Physiological Conditions
Electrochemically modulated liquid-liquid extraction (EMLLE) enables the selective extraction and separation of ions from mixtures by choice of an applied interfacial potential difference. The extraction of ionized drugs from artificial urine is reported in this paper. The artificial urine matrix wa...
| Main Authors: | , , |
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| Format: | Journal Article |
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American Chemical Society
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/31189 |
| _version_ | 1848753308008710144 |
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| author | Collins, C. Berduque, A. Arrigan, Damien |
| author_facet | Collins, C. Berduque, A. Arrigan, Damien |
| author_sort | Collins, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Electrochemically modulated liquid-liquid extraction (EMLLE) enables the selective extraction and separation of ions from mixtures by choice of an applied interfacial potential difference. The extraction of ionized drugs from artificial urine is reported in this paper. The artificial urine matrix was characterized by cyclic voltammetry at the interface between two immiscible electrolyte solutions(ITIES), showing that components of that aqueous phase truncate the available potential window at the ITIES. The transfer of three cationic drugs from aqueous artificial urine to the 1,2-dichloroethane organic electrolyte phase was examined. Both propranolol and timolol were found to transfer across the artificial urine-organic interface.However, sotalol transfer was not possible within the available potential window. Extraction of propranolol and timolol from artificial urine into an organogel phase, by electrochemically modulated liquid-liquid extraction, was examined. The application of potentials positive of the drugs’ formal transfer potentials enabled the selective extraction of both propranolol and timolol, with a higher potential being required for timolol. This work demonstrates the practical utility of EMLLE for the selective extraction of target compounds from a complex samp matrix. |
| first_indexed | 2025-11-14T08:22:27Z |
| format | Journal Article |
| id | curtin-20.500.11937-31189 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:22:27Z |
| publishDate | 2008 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-311892017-02-28T01:39:17Z Electrochemically Modulated Liquid-Liquid Extraction of Ionized Drugs under Physiological Conditions Collins, C. Berduque, A. Arrigan, Damien Electrochemically modulated liquid-liquid extraction (EMLLE) enables the selective extraction and separation of ions from mixtures by choice of an applied interfacial potential difference. The extraction of ionized drugs from artificial urine is reported in this paper. The artificial urine matrix was characterized by cyclic voltammetry at the interface between two immiscible electrolyte solutions(ITIES), showing that components of that aqueous phase truncate the available potential window at the ITIES. The transfer of three cationic drugs from aqueous artificial urine to the 1,2-dichloroethane organic electrolyte phase was examined. Both propranolol and timolol were found to transfer across the artificial urine-organic interface.However, sotalol transfer was not possible within the available potential window. Extraction of propranolol and timolol from artificial urine into an organogel phase, by electrochemically modulated liquid-liquid extraction, was examined. The application of potentials positive of the drugs’ formal transfer potentials enabled the selective extraction of both propranolol and timolol, with a higher potential being required for timolol. This work demonstrates the practical utility of EMLLE for the selective extraction of target compounds from a complex samp matrix. 2008 Journal Article http://hdl.handle.net/20.500.11937/31189 American Chemical Society restricted |
| spellingShingle | Collins, C. Berduque, A. Arrigan, Damien Electrochemically Modulated Liquid-Liquid Extraction of Ionized Drugs under Physiological Conditions |
| title | Electrochemically Modulated Liquid-Liquid Extraction of Ionized Drugs under Physiological Conditions |
| title_full | Electrochemically Modulated Liquid-Liquid Extraction of Ionized Drugs under Physiological Conditions |
| title_fullStr | Electrochemically Modulated Liquid-Liquid Extraction of Ionized Drugs under Physiological Conditions |
| title_full_unstemmed | Electrochemically Modulated Liquid-Liquid Extraction of Ionized Drugs under Physiological Conditions |
| title_short | Electrochemically Modulated Liquid-Liquid Extraction of Ionized Drugs under Physiological Conditions |
| title_sort | electrochemically modulated liquid-liquid extraction of ionized drugs under physiological conditions |
| url | http://hdl.handle.net/20.500.11937/31189 |