Joint Identification of Genetic Variants for Physical Activity inKorean Population
Abstract: There has been limited research on genome-wide association with physical activity (PA). This study ascertained genetic associations between PA and 344,893 single nucleotide polymorphism (SNP) markers in 8842 Korean samples. PA data were obtained from a validated questionnaire that included...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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MDPIAG
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/30942 |
| _version_ | 1848753235829981184 |
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| author | Kim, J. Kim, J. Min, H. Oh, S. Kim, Y. Lee, Andy Park, T. |
| author_facet | Kim, J. Kim, J. Min, H. Oh, S. Kim, Y. Lee, Andy Park, T. |
| author_sort | Kim, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Abstract: There has been limited research on genome-wide association with physical activity (PA). This study ascertained genetic associations between PA and 344,893 single nucleotide polymorphism (SNP) markers in 8842 Korean samples. PA data were obtained from a validated questionnaire that included information on PA intensity and duration. Metabolic equivalent of tasks were calculated to estimate the total daily PA level for each individual. In addition to single- and multiple-SNP association tests, a pathway enrichment analysis was performed to identify the biological significance of SNP markers. Although no significant SNP was found at genome-wide significance level via single-SNP association tests, 59 genetic variants mapped to 76 genes were identified via a multiple SNP approach using a bootstrap selection stability measure. Pathway analysis for these 59 variants showed that maturity onset diabetes of the young (MODY) was enriched. Joint identification of SNPs could enable the identification of multiple SNPs with good predictive power for PA and a pathway enriched for PA. |
| first_indexed | 2025-11-14T08:21:18Z |
| format | Journal Article |
| id | curtin-20.500.11937-30942 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:21:18Z |
| publishDate | 2014 |
| publisher | MDPIAG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-309422017-10-02T02:28:15Z Joint Identification of Genetic Variants for Physical Activity inKorean Population Kim, J. Kim, J. Min, H. Oh, S. Kim, Y. Lee, Andy Park, T. elastic-net regularization metabolic equivalent task empirical replication Abstract: There has been limited research on genome-wide association with physical activity (PA). This study ascertained genetic associations between PA and 344,893 single nucleotide polymorphism (SNP) markers in 8842 Korean samples. PA data were obtained from a validated questionnaire that included information on PA intensity and duration. Metabolic equivalent of tasks were calculated to estimate the total daily PA level for each individual. In addition to single- and multiple-SNP association tests, a pathway enrichment analysis was performed to identify the biological significance of SNP markers. Although no significant SNP was found at genome-wide significance level via single-SNP association tests, 59 genetic variants mapped to 76 genes were identified via a multiple SNP approach using a bootstrap selection stability measure. Pathway analysis for these 59 variants showed that maturity onset diabetes of the young (MODY) was enriched. Joint identification of SNPs could enable the identification of multiple SNPs with good predictive power for PA and a pathway enriched for PA. 2014 Journal Article http://hdl.handle.net/20.500.11937/30942 10.3390/ijms150712407 MDPIAG fulltext |
| spellingShingle | elastic-net regularization metabolic equivalent task empirical replication Kim, J. Kim, J. Min, H. Oh, S. Kim, Y. Lee, Andy Park, T. Joint Identification of Genetic Variants for Physical Activity inKorean Population |
| title | Joint Identification of Genetic Variants for Physical Activity inKorean Population |
| title_full | Joint Identification of Genetic Variants for Physical Activity inKorean Population |
| title_fullStr | Joint Identification of Genetic Variants for Physical Activity inKorean Population |
| title_full_unstemmed | Joint Identification of Genetic Variants for Physical Activity inKorean Population |
| title_short | Joint Identification of Genetic Variants for Physical Activity inKorean Population |
| title_sort | joint identification of genetic variants for physical activity inkorean population |
| topic | elastic-net regularization metabolic equivalent task empirical replication |
| url | http://hdl.handle.net/20.500.11937/30942 |