Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening

QR Code

Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening

The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key finding...

Full description

Bibliographic Details
Main Authors:	Gunosewoyo, Hendra, Coster, M., Bennett, M., Kassiou, M.
Format:	Journal Article
Published:	Pergamon 2009
Subjects:	P2X7 antagonists LL-37 Rational drug design Cytokine release
Online Access:	http://hdl.handle.net/20.500.11937/30938

Similar Items

Cubyl amides: Novel P2X7 receptor antagonists
by: Gunosewoyo, Hendra, et al.
Published: (2008)

Molecular Probes for P2X7 Receptor Studies
by: Gunosewoyo, Hendra, et al.
Published: (2007)

P2X purinergic receptor ligands: recently patented compounds
by: Gunosewoyo, Hendra, et al.
Published: (2010)

The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity
by: Wilkinson, S., et al.
Published: (2014)

Design, Synthesis, and Evaluation of New P2Y2 Receptor Antagonists and Fluorescent Ligands
by: Knight, Rebecca
Published: (2025)

Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists
by: Kindon, Nicholas, et al.
Published: (2017)

Discovery of fevipiprant (NVP-QAW039), a potent and selective DP2 receptor antagonist for treatment of asthma
by: Sandham, David A., et al.
Published: (2017)

Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation
by: Riabov, Vladimir, et al.
Published: (2017)

Potential Of Selected Antagonistic Bacteria In Controlling Damping-Off Disease Of Brassica Chinensis L. Caused By Pythium Myriotylum Drech
by: Zahara, Hafni
Published: (2004)

Characterization of Pectobacterium carotovorum and P. wasabiae and their potential control using antagonistic bacteria
by: Golkhandan, Elham
Published: (2014)

Additive manufacturing of affinity hydrogels for controlled biomacromolecule delivery in early osteoarthritis
by: Loxley, George
Published: (2023)

The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition
by: Cheong, S., et al.
Published: (2010)

Synthesis and biological evaluation of novel PqsR antagonists to combat Pseudomonas aeruginosa infections
by: Mashabi, Alaa
Published: (2021)

From UTP to AR-C118925, the discovery of a potent non nucleotide antagonist of the P2Y2 receptor
by: Kindon, Nicholas, et al.
Published: (2017)

Synthesis and evaluation of the first fluorescent antagonists of the human P2Y2 receptor based on AR-C118925
by: Conroy, Sean, et al.
Published: (2018)

Potential use of selected antagonistic bacteria to control foot rot disease of black pepper (Piper nigrum L.) in Sarawak, Malaysia
by: Md Daut, Siti Noor Farhana
Published: (2014)

Antagonistic Activities of Epiphytic Bacteria on Black Pod Disease of Cocoa
by: Mohd Jaaffar, Ahmad Kamil
Published: (2004)

B-blockers, calcium antagonists, and mortality in stable coronary artery disease: An international cohort study
by: Sorbets, E., et al.
Published: (2019)

Graduation Form 7GF (Coursework)
by: Universiti Malaysia Sarawak, Centre for Graduate Studies
Published: (2016)

Graduation Form 7GF(By Research)
by: Universiti Malaysia Sarawak, Centre for Graduate Studies
Published: (2016)

Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT₆ receptor antagonist SB-399885
by: Shortall, Sinead E., et al.
Published: (2018)

Release currents of IP₃ receptor channel clusters and concentration profiles
by: Thul, Ruediger, et al.
Published: (2004)

Structural investigation of Pseudomonas aeruginosa quorum sensing receptor PqsR to aid virulence inhibition
by: Richardson, William
Published: (2022)

Illuminating the life of the adenosine receptors: development and application of subtype-selective fluorescent probes for the study of the human A1 and A2A adenosine receptors in living cells
by: Comeo, Eleonora
Published: (2022)

Current and emerging therapies for corneal infection: a clinical and laboratory study
by: Ting, Darren Shu Jeng
Published: (2022)

Cytotoxic T-Lymphotyces antigen 4 gene polymorphism and cytokine levels among severe haemophilia a patients with and without inhibitors
by: Nadarajan, Anantha Kummar
Published: (2020)

Role of RhoGDIα on migration and invasion of estrogen receptor positive MCF7 and estrogen receptor negative MDA-MB-231 breast cancer cells
by: Hooshmand, Somayeh
Published: (2014)

Calcium antagonists-induced lower urinary tract symptoms
by: Elhebir, Elsamaul Suliman A.
Published: (2011)

Imaging Cannabinoid Receptors: A Brief Collection of Covalent and Fluorescent Probes for CB1 and CB2 Receptors
by: Hamilton, A.J., et al.
Published: (2021)

Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy
by: Sun, H., et al.
Published: (2016)

Endocrine and immune responses to resistance training in prostate cancer patients
by: Galvao, D, et al.
Published: (2008)

Paediatric rational prescribing: a study of paediatric rational prescribing tools and development of a novel tool for the UK
by: Corrick, Fenella J.
Published: (2021)

Effect of memantine on rat and human NMDA receptors in comparison with harmonia axyridis extract
by: Rehman, Abdul
Published: (2023)

What drives stock prices? Fundamentals, bubbles and investor behavior.
by: Chen, Y., et al.
Published: (2009)

Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus
by: Glynn, Danielle J., et al.
Published: (2017)

Dynamics of cytokine induced E-selectin expression in endothelial cells
by: Ogrodzinski, Lydia
Published: (2023)

Associations between immunologically - related genetic polymorphisms and cytokines expression on human leptospirosis susceptibility and severity
by: Wan Yusoff, Wan Shahriman Yushdie
Published: (2021)

Evaluation of Electrospun Nanofibrous Structures for Drug Release Application
by: Haroosh, Hazim Jasim Mohammed, et al.
Published: (2014)

Abstract Swiss cheese space and classicalisation of Swiss cheeses
by: Feinstein, Joel, et al.
Published: (2016)

Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents
by: Adams, James, et al.
Published: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0le2k0c2nfuor982bkd5j0hvei