Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening
The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key finding...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Pergamon
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/30938 |
| _version_ | 1848753234528698368 |
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| author | Gunosewoyo, Hendra Coster, M. Bennett, M. Kassiou, M. |
| author_facet | Gunosewoyo, Hendra Coster, M. Bennett, M. Kassiou, M. |
| author_sort | Gunosewoyo, Hendra |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry. |
| first_indexed | 2025-11-14T08:21:17Z |
| format | Journal Article |
| id | curtin-20.500.11937-30938 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:21:17Z |
| publishDate | 2009 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-309382017-09-13T15:14:33Z Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening Gunosewoyo, Hendra Coster, M. Bennett, M. Kassiou, M. P2X7 antagonists LL-37 Rational drug design Cytokine release The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry. 2009 Journal Article http://hdl.handle.net/20.500.11937/30938 10.1016/j.bmc.2009.05.083 Pergamon restricted |
| spellingShingle | P2X7 antagonists LL-37 Rational drug design Cytokine release Gunosewoyo, Hendra Coster, M. Bennett, M. Kassiou, M. Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening |
| title | Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening |
| title_full | Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening |
| title_fullStr | Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening |
| title_full_unstemmed | Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening |
| title_short | Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening |
| title_sort | purinergic p2x7 receptor antagonists: chemistry and fundamentals of biological screening |
| topic | P2X7 antagonists LL-37 Rational drug design Cytokine release |
| url | http://hdl.handle.net/20.500.11937/30938 |