Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life
© 2014 John Wiley & Sons A/S. Introduction: Asthma is associated with diminished health-related quality of life (HRQoL). Particularly in adolescence, asthma may be under-diagnosed and undertreated or poorly managed. Therefore, we aimed to determine the association between childhood wheezing phen...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Blackwell Publishing Ltd
2014
|
| Online Access: | http://hdl.handle.net/20.500.11937/30452 |
| _version_ | 1848753093112496128 |
|---|---|
| author | Braig, S. Brandt, S. Wabitsch, M. Florath, Ines Brenner, H. Rothenbacher, D. Genuneit, J. |
| author_facet | Braig, S. Brandt, S. Wabitsch, M. Florath, Ines Brenner, H. Rothenbacher, D. Genuneit, J. |
| author_sort | Braig, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2014 John Wiley & Sons A/S. Introduction: Asthma is associated with diminished health-related quality of life (HRQoL). Particularly in adolescence, asthma may be under-diagnosed and undertreated or poorly managed. Therefore, we aimed to determine the association between childhood wheezing phenotypes rather than asthma and adolescent HRQoL in children aged 10-17 yr. Methods: We analyzed the data from two prospective population-based cohort studies (n = 604 and n = 1804) conducted in southern Germany with baseline assessments in 2000 and 2006 and follow-ups at frequent intervals. Parent-reported wheeze was categorized into never, early transient, persistent, and late-onset wheeze. We assessed child-reported HRQoL in seven scales using the validated KINDL-R. Multivariate linear regression models were computed. Results: Participants with late-onset wheeze had significantly lower values in all HRQoL scales, but physical well-being compared to never wheezers. Early transient wheeze was negatively associated with three HRQoL scales only (family, school, and total). These effects were confined to the oldest age group (=13.5 yr) in one study. Persistent wheeze was not associated with HRQoL. Conclusions: In teenagers, late-onset wheezers seem to be particularly vulnerable for impairments in psychosocial aspects of health-related quality of life. |
| first_indexed | 2025-11-14T08:19:02Z |
| format | Journal Article |
| id | curtin-20.500.11937-30452 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:19:02Z |
| publishDate | 2014 |
| publisher | Blackwell Publishing Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-304522017-09-13T15:32:48Z Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life Braig, S. Brandt, S. Wabitsch, M. Florath, Ines Brenner, H. Rothenbacher, D. Genuneit, J. © 2014 John Wiley & Sons A/S. Introduction: Asthma is associated with diminished health-related quality of life (HRQoL). Particularly in adolescence, asthma may be under-diagnosed and undertreated or poorly managed. Therefore, we aimed to determine the association between childhood wheezing phenotypes rather than asthma and adolescent HRQoL in children aged 10-17 yr. Methods: We analyzed the data from two prospective population-based cohort studies (n = 604 and n = 1804) conducted in southern Germany with baseline assessments in 2000 and 2006 and follow-ups at frequent intervals. Parent-reported wheeze was categorized into never, early transient, persistent, and late-onset wheeze. We assessed child-reported HRQoL in seven scales using the validated KINDL-R. Multivariate linear regression models were computed. Results: Participants with late-onset wheeze had significantly lower values in all HRQoL scales, but physical well-being compared to never wheezers. Early transient wheeze was negatively associated with three HRQoL scales only (family, school, and total). These effects were confined to the oldest age group (=13.5 yr) in one study. Persistent wheeze was not associated with HRQoL. Conclusions: In teenagers, late-onset wheezers seem to be particularly vulnerable for impairments in psychosocial aspects of health-related quality of life. 2014 Journal Article http://hdl.handle.net/20.500.11937/30452 10.1111/pai.12280 Blackwell Publishing Ltd restricted |
| spellingShingle | Braig, S. Brandt, S. Wabitsch, M. Florath, Ines Brenner, H. Rothenbacher, D. Genuneit, J. Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life |
| title | Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life |
| title_full | Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life |
| title_fullStr | Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life |
| title_full_unstemmed | Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life |
| title_short | Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life |
| title_sort | age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life |
| url | http://hdl.handle.net/20.500.11937/30452 |