A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients
Introduction Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort....
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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2013
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| Online Access: | http://hdl.handle.net/20.500.11937/30435 |
| _version_ | 1848753088434798592 |
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| author | Wadley, A. Kamerman, P. Chew, C. Lombard, Z. Cherry, C. Price, Patricia |
| author_facet | Wadley, A. Kamerman, P. Chew, C. Lombard, Z. Cherry, C. Price, Patricia |
| author_sort | Wadley, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Introduction Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. Method 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. Results IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. Discussion We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation. © 2013 Elsevier Ltd. |
| first_indexed | 2025-11-14T08:18:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-30435 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:18:57Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-304352017-09-13T15:32:24Z A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients Wadley, A. Kamerman, P. Chew, C. Lombard, Z. Cherry, C. Price, Patricia Introduction Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. Method 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. Results IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. Discussion We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation. © 2013 Elsevier Ltd. 2013 Journal Article http://hdl.handle.net/20.500.11937/30435 10.1016/j.molimm.2013.02.002 restricted |
| spellingShingle | Wadley, A. Kamerman, P. Chew, C. Lombard, Z. Cherry, C. Price, Patricia A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients |
| title | A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients |
| title_full | A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients |
| title_fullStr | A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients |
| title_full_unstemmed | A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients |
| title_short | A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients |
| title_sort | polymorphism in il4 may associate with sensory neuropathy in african hiv patients |
| url | http://hdl.handle.net/20.500.11937/30435 |