TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors
Associations between major histocompatibility complex (MHC) ancestral haplotypes (AHs) and immunopathological diseases are traditionally ascribed to human leukocyte antigen (HLA) class I or class II alleles. However, polymorphisms in TNF and nearby genes in the central MHC can influence risk. We hav...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Blackwell Munksgaard
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/30298 |
| _version_ | 1848753048500830208 |
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| author | Valente, F. Tan, C. Phipps, M. Witt, C. Kaur, G. Gut, I. Allcock, R. Price, Patricia |
| author_facet | Valente, F. Tan, C. Phipps, M. Witt, C. Kaur, G. Gut, I. Allcock, R. Price, Patricia |
| author_sort | Valente, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Associations between major histocompatibility complex (MHC) ancestral haplotypes (AHs) and immunopathological diseases are traditionally ascribed to human leukocyte antigen (HLA) class I or class II alleles. However, polymorphisms in TNF and nearby genes in the central MHC can influence risk. We have defined TNF block haplotypes in Asian, European and Australian Aboriginal donors and shown conservation of TNF block haplotypes in geographically distinct populations, consistent with a common evolutionary origin. Here we show that most TNF block haplotypes do not align with a single MHC AH and associations often vary with ethnicity. This suggests more recent recombination events between the TNF block and the HLA alleles. © 2009 John Wiley & Sons A/S. |
| first_indexed | 2025-11-14T08:18:19Z |
| format | Journal Article |
| id | curtin-20.500.11937-30298 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:18:19Z |
| publishDate | 2009 |
| publisher | Blackwell Munksgaard |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-302982017-09-13T15:30:51Z TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors Valente, F. Tan, C. Phipps, M. Witt, C. Kaur, G. Gut, I. Allcock, R. Price, Patricia Associations between major histocompatibility complex (MHC) ancestral haplotypes (AHs) and immunopathological diseases are traditionally ascribed to human leukocyte antigen (HLA) class I or class II alleles. However, polymorphisms in TNF and nearby genes in the central MHC can influence risk. We have defined TNF block haplotypes in Asian, European and Australian Aboriginal donors and shown conservation of TNF block haplotypes in geographically distinct populations, consistent with a common evolutionary origin. Here we show that most TNF block haplotypes do not align with a single MHC AH and associations often vary with ethnicity. This suggests more recent recombination events between the TNF block and the HLA alleles. © 2009 John Wiley & Sons A/S. 2009 Journal Article http://hdl.handle.net/20.500.11937/30298 10.1111/j.1399-0039.2009.01258.x Blackwell Munksgaard restricted |
| spellingShingle | Valente, F. Tan, C. Phipps, M. Witt, C. Kaur, G. Gut, I. Allcock, R. Price, Patricia TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors |
| title | TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors |
| title_full | TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors |
| title_fullStr | TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors |
| title_full_unstemmed | TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors |
| title_short | TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors |
| title_sort | tnf block haplotypes associated with conserved mhc haplotypes in european, asian and australian aboriginal donors |
| url | http://hdl.handle.net/20.500.11937/30298 |