The potential regulatory role of Vitamin D in the bioenergetics of inflammation
Purpose of review The extraskeletal health benefits of vitamin D still need scientific endorsement. Obesity and related chronic diseases are pathogenically linked by inflammation, which carries a considerable energetic cost. Recent techniques for the determination of the bioenergetic demand of infla...
| Main Authors: | , , |
|---|---|
| Format: | Journal Article |
| Published: |
Lippincott Williams and Wilkins
2015
|
| Online Access: | http://hdl.handle.net/20.500.11937/30241 |
| _version_ | 1848753032123121664 |
|---|---|
| author | Calton, E. Keane, Kevin Soares, Mario |
| author_facet | Calton, E. Keane, Kevin Soares, Mario |
| author_sort | Calton, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purpose of review The extraskeletal health benefits of vitamin D still need scientific endorsement. Obesity and related chronic diseases are pathogenically linked by inflammation, which carries a considerable energetic cost. Recent techniques for the determination of the bioenergetic demand of inflammation, offer an avenue to cement the regulatory role of vitamin D in this process. Recent findings Nuclear vitamin D receptors may be translocated into mitochondria of certain cell types, opening up a pathway for direct action on cellular bioenergetics. Classical M1 (inflammatory)/M2(anti-inflammatory) phenotypes can vary with the clinical context. M2 macrophages do not always depend on oxidative metabolism/fatty acid oxidation. Newer methodologies offer real-time bioenergetic measurements that can be used as an index of metabolic health. Summary Vitamin D may prove to be a therapeutic agent for inflammation of chronic disease and understanding its role in cellular bioenergetics may offer a diagnostic/prognostic indicator of its action. |
| first_indexed | 2025-11-14T08:18:04Z |
| format | Journal Article |
| id | curtin-20.500.11937-30241 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:18:04Z |
| publishDate | 2015 |
| publisher | Lippincott Williams and Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-302412017-09-13T15:30:24Z The potential regulatory role of Vitamin D in the bioenergetics of inflammation Calton, E. Keane, Kevin Soares, Mario Purpose of review The extraskeletal health benefits of vitamin D still need scientific endorsement. Obesity and related chronic diseases are pathogenically linked by inflammation, which carries a considerable energetic cost. Recent techniques for the determination of the bioenergetic demand of inflammation, offer an avenue to cement the regulatory role of vitamin D in this process. Recent findings Nuclear vitamin D receptors may be translocated into mitochondria of certain cell types, opening up a pathway for direct action on cellular bioenergetics. Classical M1 (inflammatory)/M2(anti-inflammatory) phenotypes can vary with the clinical context. M2 macrophages do not always depend on oxidative metabolism/fatty acid oxidation. Newer methodologies offer real-time bioenergetic measurements that can be used as an index of metabolic health. Summary Vitamin D may prove to be a therapeutic agent for inflammation of chronic disease and understanding its role in cellular bioenergetics may offer a diagnostic/prognostic indicator of its action. 2015 Journal Article http://hdl.handle.net/20.500.11937/30241 10.1097/MCO.0000000000000186 Lippincott Williams and Wilkins restricted |
| spellingShingle | Calton, E. Keane, Kevin Soares, Mario The potential regulatory role of Vitamin D in the bioenergetics of inflammation |
| title | The potential regulatory role of Vitamin D in the bioenergetics of inflammation |
| title_full | The potential regulatory role of Vitamin D in the bioenergetics of inflammation |
| title_fullStr | The potential regulatory role of Vitamin D in the bioenergetics of inflammation |
| title_full_unstemmed | The potential regulatory role of Vitamin D in the bioenergetics of inflammation |
| title_short | The potential regulatory role of Vitamin D in the bioenergetics of inflammation |
| title_sort | potential regulatory role of vitamin d in the bioenergetics of inflammation |
| url | http://hdl.handle.net/20.500.11937/30241 |