SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease

QR Code

SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease

The extracellular ligand, Wnt, and its receptors are involved in sign al transduction and play an important role in axis formation and neural development. In neurodegenerative disorders such as Alzheimer's disease (AD), a decrease of the intracellular Wnt effector, ß-catenin, has been linked to...

Full description

Bibliographic Details
Main Authors:	Warrier, Sudha, Marimuthu, R., Sekhar, S., Bhuvanalakshmi, G., Arfuso, Frank, Das, A., Bhonde, R., Martins, R., Dharmarajan, Arunasalam
Format:	Journal Article
Published:	Pergamon 2016
Online Access:	http://hdl.handle.net/20.500.11937/30058

Similar Items

Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma
by: Bhuvanalakshmi, G., et al.
Published: (2019)

Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition
by: Warrier, Sudha, et al.
Published: (2014)

Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators
by: Bhuvanalakshmi, G., et al.
Published: (2017)

Multifunctional Properties of Chicken Embryonic Prenatal Mesenchymal Stem Cells- Pluripotency, Plasticity, and Tumor Suppression
by: Bhuvanalakshmi, G., et al.
Published: (2014)

The Wnt regulator SFRP4 inhibits mesothelioma cell proliferation, migration, and antagonizes Wnt3a via its netrin-like domain
by: Perumal, Vanathi, et al.
Published: (2017)

Wnt antagonist, secreted frizzled-related protein 4 (sFRP4), increases chemotherapeutic response of glioma stem-like cells
by: Warrier, S., et al.
Published: (2014)

Wnt antagonist, secreted frizzled-related protein 4 (SFRP4) and peptides from its associated domains, increases chemotherapeutic response of cancer stem cells of malignant mesothelioma cell lines
by: Perumal, V., et al.
Published: (2017)

SFRP-4 abrogates Wnt-3a-induced ß-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation
by: Constantinou, T., et al.
Published: (2008)

Breast cancer stem-like cells are inhibited by diosgenin, a steroidal saponin, by the attenuation of the Wnt ß-catenin signaling via the Wnt antagonist secreted frizzled related protein-4
by: Bhuvanalakshmi, G., et al.
Published: (2017)

Role of Wnt signalling in early pregnancy
by: Nayeem, S., et al.
Published: (2015)

Epigenetic demthylation of sFRPs, with emphasis on sFRP4 activation, leading to Wnt signalling suppression and histone modifications in breast, prostate, and ovary cancer stem cells.
by: Deshmukh, A., et al.
Published: (2019)

Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt
by: Visweswaran, Malini, et al.
Published: (2015)

Secreted frizzled-related protein 4 inhibits glioma stem-like cells by reversing epithelial to mesenchymal transition, inducing apoptosis and decreasing cancer stem cell properties
by: Bhuvanalakshmi, G., et al.
Published: (2015)

Regulation of cancer stem cell metabolism by secreted frizzled-related protein 4 (SFRP4)
by: Deshmukh, Abhijeet, et al.
Published: (2018)

‘Lnc’-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling
by: Ong, M., et al.
Published: (2017)

The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line
by: McLaren, S., et al.
Published: (2014)

Therapeutic approach to target mesothelioma cancer cells using the Wnt antagonist, secreted frizzled-related protein 4: Metabolic state of cancer cells
by: Perumal, Vanathi, et al.
Published: (2015)

Wnt signaling in triple-negative breast cancer
by: Pohl, S., et al.
Published: (2017)

The role of Wnt signalling in angiogenesis
by: Olsen, J., et al.
Published: (2017)

The inhibitory influence of adipose tissue-derived mesenchymal stem cell environment and Wnt antagonism on breast tumour cell lines
by: Visweswaran, M., et al.
Published: (2017)

Number and brightness analysis of sFRP4 domains in live cells demonstrates vesicle association signal of the NLD domain and dynamic intracellular responses to Wnt3a
by: Perumal, V., et al.
Published: (2015)

Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays
by: Berry, A., et al.
Published: (2014)

Secreted Frizzled-related protein 4 (sFRP4) chemo-sensitizes cancer stem cells derived from human breast, prostate, and ovary tumor cell lines
by: Deshmukh, A., et al.
Published: (2017)

The Influence of Breast Tumour-Derived Factors and Wnt Antagonism on the Transformation of Adipose-Derived Mesenchymal Stem Cells into Tumour-Associated Fibroblasts
by: Visweswaran, M., et al.
Published: (2018)

Wnt antagonist secreted frizzled-related protein 4 upregulates adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells
by: Visweswaran, Malini, et al.
Published: (2015)

Winding back Wnt signalling: Potential therapeutic targets for treating gastric cancers
by: Flanagan, D., et al.
Published: (2017)

Inherent propensity of amnion-derived mesenchymal stem cells towards endothelial lineage: Vascularization from an avascular tissue
by: Warrier, Sudha, et al.
Published: (2012)

Breast cancer bone metastases: pathogenesis and therapeutic targets
by: Brook, Naomi, et al.
Published: (2018)

A synthetic formulation, Dhanwantharam kashaya, delays senescence in stem cells
by: Warrier, S, et al.
Published: (2013)

Secreted Frizzled related protein-4 (sFRP4) promotes epidermal differentiation and apoptosis
by: Maganga, R., et al.
Published: (2008)

SFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium
by: Saran, U., et al.
Published: (2017)

Insights into the pathophysiology of Alzheimers disease and potential therapeutic targets: a current perspective
by: Rajah Kumaran, Kesevan, et al.
Published: (2023)

Insights into the pathophysiology of Alzheimer's disease and potential therapeutic targets: a current perspective
by: Kesevan, Rajah Kumaran, et al.
Published: (2023)

Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domain
by: Agostino, M., et al.
Published: (2017)

Paracrine communication modulates production of Wnt antagonists and COX1-mediated prostaglandins in a decidual-trophoblast co-culture model
by: Nayeem, S., et al.
Published: (2015)

Clearance mechanisms of Alzheimer’s amyloid-b peptide: implications for therapeutic design and diagnostic tests
by: Bates, K., et al.
Published: (2009)

Epigenetic regulation of the secreted frizzled-related protein family in human glioblastoma multiforme
by: Schiefer, L., et al.
Published: (2014)

Latrepirdine: Molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases
by: Bharadwaj, P., et al.
Published: (2013)

Secreted frizzled related proteins: Implications in cancers
by: Surana, R., et al.
Published: (2014)

Secreted frizzled-related protein 4 and its implications in cancer and apoptosis
by: Pohl, S., et al.
Published: (2015)