SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease
The extracellular ligand, Wnt, and its receptors are involved in sign al transduction and play an important role in axis formation and neural development. In neurodegenerative disorders such as Alzheimer's disease (AD), a decrease of the intracellular Wnt effector, ß-catenin, has been linked to...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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Pergamon
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/30058 |
| _version_ | 1848752978554519552 |
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| author | Warrier, Sudha Marimuthu, R. Sekhar, S. Bhuvanalakshmi, G. Arfuso, Frank Das, A. Bhonde, R. Martins, R. Dharmarajan, Arunasalam |
| author_facet | Warrier, Sudha Marimuthu, R. Sekhar, S. Bhuvanalakshmi, G. Arfuso, Frank Das, A. Bhonde, R. Martins, R. Dharmarajan, Arunasalam |
| author_sort | Warrier, Sudha |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The extracellular ligand, Wnt, and its receptors are involved in sign al transduction and play an important role in axis formation and neural development. In neurodegenerative disorders such as Alzheimer's disease (AD), a decrease of the intracellular Wnt effector, ß-catenin, has been linked to amyloid-ß-peptide-induced neurotoxicity. Despite this knowledge, targeting Wnt inhibitors as potential biomarkers has not been explored, and harnessing Wnt activators as therapeutic candidates remains largely not investigated. A wide acting family of Wnt mediators, secreted frizzled-related proteins (sFRPs), has not been probed so far as molecular indicators of disease occurrence and progression of Alzheimer's. Unlike the effect of the Dickkopf (DKK) family of Wnt antagonists on AD, the sFRP molecules have a more pleiotropic impact on the Wnt signaling cascade and probably have a far-reaching involvement in neurodegeneration. The role of sFRPs has been poorly described in AD, and in this review, we analyze the present status of the role of sFRPs on neurodegeneration, their likely involvement, and potential implications in treatment modalities of AD. This information would provide valuable clues for the development of potential therapeutic targets for aberrant neurodegenerative disorders. |
| first_indexed | 2025-11-14T08:17:12Z |
| format | Journal Article |
| id | curtin-20.500.11937-30058 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:17:12Z |
| publishDate | 2016 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-300582017-09-13T15:37:43Z SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease Warrier, Sudha Marimuthu, R. Sekhar, S. Bhuvanalakshmi, G. Arfuso, Frank Das, A. Bhonde, R. Martins, R. Dharmarajan, Arunasalam The extracellular ligand, Wnt, and its receptors are involved in sign al transduction and play an important role in axis formation and neural development. In neurodegenerative disorders such as Alzheimer's disease (AD), a decrease of the intracellular Wnt effector, ß-catenin, has been linked to amyloid-ß-peptide-induced neurotoxicity. Despite this knowledge, targeting Wnt inhibitors as potential biomarkers has not been explored, and harnessing Wnt activators as therapeutic candidates remains largely not investigated. A wide acting family of Wnt mediators, secreted frizzled-related proteins (sFRPs), has not been probed so far as molecular indicators of disease occurrence and progression of Alzheimer's. Unlike the effect of the Dickkopf (DKK) family of Wnt antagonists on AD, the sFRP molecules have a more pleiotropic impact on the Wnt signaling cascade and probably have a far-reaching involvement in neurodegeneration. The role of sFRPs has been poorly described in AD, and in this review, we analyze the present status of the role of sFRPs on neurodegeneration, their likely involvement, and potential implications in treatment modalities of AD. This information would provide valuable clues for the development of potential therapeutic targets for aberrant neurodegenerative disorders. 2016 Journal Article http://hdl.handle.net/20.500.11937/30058 10.1016/j.biocel.2016.04.002 Pergamon fulltext |
| spellingShingle | Warrier, Sudha Marimuthu, R. Sekhar, S. Bhuvanalakshmi, G. Arfuso, Frank Das, A. Bhonde, R. Martins, R. Dharmarajan, Arunasalam SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease |
| title | SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease |
| title_full | SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease |
| title_fullStr | SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease |
| title_full_unstemmed | SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease |
| title_short | SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease |
| title_sort | sfrp-mediated wnt sequestration as a potential therapeutic target for alzheimer's disease |
| url | http://hdl.handle.net/20.500.11937/30058 |