Genotype × age interaction in human transcriptional ageing

QR Code

Genotype × age interaction in human transcriptional ageing

Individual differences in biological ageing (i.e., the rate of physiological response to the passage of time) may be due in part to genotype-specific variation in gene action. However, the sources of heritable variation in human age-related gene expression profiles are largely unknown. We have profi...

Full description

Bibliographic Details
Main Authors:	Kent, J., Göring, H., Charlesworth, J., Drigalenko, E., Diego, V., Curran, J., Johnson, M., Dyer, T., Cole, S., Jowett, J., Mahaney, M., Comuzzie, A., Almasy, L., Moses, Eric, Blangero, J., Williams-Blangero, S.
Format:	Journal Article
Published:	2012
Online Access:	http://hdl.handle.net/20.500.11937/2992

Similar Items

Systems genetics of the nuclear factor-?B signal transduction network. I. Detection of several quantitative trait loci potentially relevant to aging
by: Diego, V., et al.
Published: (2012)

Transcriptomic epidemiology of smoking: The effect of smoking on gene expression in lymphocytes
by: Charlesworth, J., et al.
Published: (2010)

Genetic variation at the FTO locus influences RBL2 gene expression
by: Jowett, J., et al.
Published: (2010)

Genetic architecture of carotid artery intima-media thickness in Mexican Americans
by: Melton, P., et al.
Published: (2013)

Transcriptomics of cortical gray matter thickness decline during normal aging
by: Kochunov, P., et al.
Published: (2013)

Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon
by: Tejero, M., et al.
Published: (2008)

GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans
by: Chittoor, G., et al.
Published: (2016)

Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans
by: Voruganti, V., et al.
Published: (2013)

Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens
by: Rubicz, R., et al.
Published: (2014)

Effects of copy number variable regions on local gene expression in white blood cells of Mexican Americans
by: Blackburn, A., et al.
Published: (2015)

High dimensional endophenotype ranking in the search for major depression risk genes
by: Glahn, D., et al.
Published: (2012)

Plasma levels of soluble interleukin 1 receptor accessory protein are reduced in obesity
by: Bozaoglu, K., et al.
Published: (2014)

The transcriptional landscape of age in human peripheral blood
by: Peters, M., et al.
Published: (2015)

Genome-wide genetic investigation of serological measures of common infections
by: Rubicz, R., et al.
Published: (2015)

Genetic signal maximization using environmental regression.
by: Melton, Phillip, et al.
Published: (2011)

A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)
by: Rubicz, R., et al.
Published: (2013)

The 57 kb deletion in cystinosis patients extends into TRPV1 causing dysregulation of transcription in peripheral blood mononuclear cells
by: Freed, K., et al.
Published: (2011)

Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes
by: Carless, M., et al.
Published: (2011)

Genetical genomics of Th1 and Th2 immune response in a baboon model of atherosclerosis risk factors
by: Vinson, A., et al.
Published: (2011)

Chemerin, a novel adipokine in the regulation of angiogenesis
by: Bozaoglu, K., et al.
Published: (2010)

Genetic association of preeclampsia to the inflammatory response gene SEPS1
by: Moses, Eric, et al.
Published: (2008)

A transcriptional profile of the decidua in preeclampsia
by: Løset, M., et al.
Published: (2011)

Genetic variation in PARL influences mitochondrial content
by: Curran, J., et al.
Published: (2010)

Genome wide association and pathway analysis of segment-specific carotid intima-media thickness phenotypes: The San Antonio Family Heart Study
by: Melton, Phillip, et al.
Published: (2011)

P-selectin expression tracks cerebral atrophy in Mexican-Americans
by: Kochunov, P., et al.
Published: (2012)

ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-a
by: Jowett, J., et al.
Published: (2012)

Bivariate genetic association of KIAA1797 with heart rate in American Indians: The Strong Heart Family Study
by: Melton, P., et al.
Published: (2010)

Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia
by: Fitzpatrick, E., et al.
Published: (2009)

TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis
by: Lake, N., et al.
Published: (2017)

Variants in CPT1A, FADS1, and FADS2 are associated with higher levels of estimated plasma and erythrocyte delta-5 desaturases in Alaskan Eskimos
by: Voruganti, V., et al.
Published: (2012)

ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice
by: Weerasekera, L., et al.
Published: (2017)

Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study)
by: Roten, L., et al.
Published: (2009)

The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations
by: Johnson, M., et al.
Published: (2009)

Finding potential cis-regulatory loci using allele-specific chromatin accessibility as weights in a kernel-based variance component test
by: Peralta, J., et al.
Published: (2016)

INSIG1 infl uences obesity-related hypertriglyceridemia in humans
by: Smith, E., et al.
Published: (2010)

Pleiotropy of cardiometabolic syndrome with obesity-related anthropometric traits determined using empirically derived kinships from the Busselton Health Study
by: Cadby, G., et al.
Published: (2017)

The characterization of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome
by: Prior, M., et al.
Published: (2010)

Identification of ACOX2 as a shared genetic risk factor for preeclampsia and cardiovascular disease
by: Johansson, A., et al.
Published: (2011)

Localization of a major susceptibility locus influencing preterm birth
by: Chittoor, G., et al.
Published: (2013)

Corrigendum to " Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases" [Biochem. Biophys. Res. Commun. 417 (2012) 653-658]
by: Kaskow, B., et al.
Published: (2012)