PI3K Class II [alpha] Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

PI3K Class II [alpha] Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

Multiple phosphatidylinositol (PtdIns) 3-kinases (PI3Ks) can produce PtdIns3P to control endocytic trafficking, but whether enzyme specialization occurs in defined subcellular locations is unclear. Here, we report that PI3K-C2a is enriched in the pericentriolar recycling endocytic compartment (PRE)...

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Bibliographic Details
Main Authors: Franco, I., Gulluni, F., Campa, C., Costa, C., Margaria, J., Ciraolo, E., Martini, M., Monteyne, D., De Luca, E., Germena, G., Posor, Y., Maffucci, T., Marengo, S., Haucke, V., Falasca, Marco, Perez-Morga, D., Boletta, A., Merlo, G., Hirsch, E.
Format: Journal Article
Published: Cell Press 2014
Online Access:http://hdl.handle.net/20.500.11937/29649

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