Phenotype refinement for comorbid Attention Deficit Hyperactivity Disorder and reading disability
Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and reading disability (RD) is common; however, the heritability of this comorbidity is not well understood. This may be due to the complexity and heterogeneity of ADHD and RD phenotypes. Using alternative ADHD–RD sub-phenotypes ins...
| Main Authors: | , , , |
|---|---|
| Format: | Journal Article |
| Published: |
John Wiley and Sons, Inc
2012
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/29454 |
| _version_ | 1848752807910309888 |
|---|---|
| author | Sheikhi, A. Martin, Neilson Hay, David Piek, Jan |
| author_facet | Sheikhi, A. Martin, Neilson Hay, David Piek, Jan |
| author_sort | Sheikhi, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and reading disability (RD) is common; however, the heritability of this comorbidity is not well understood. This may be due to the complexity and heterogeneity of ADHD and RD phenotypes. Using alternative ADHD–RD sub-phenotypes instead of those arising from the DSM-IV may lead to greater success in the search for comorbid ADHD–RD susceptibility genes. Therefore, this study aims to refine ADHD–RD phenotypes into homogenous informative sub-phenotypes using latent class analysis (LCA). LCA was performed on 2,610 Australian twin families (6,535 individuals) in order to generate probabilistic genetically distinct classes that define ADHD–RD subtypes, including comorbidity, based on related symptom clusters. The LCA separated the phenotypes for ADHD and RD into nine classes. One class was unaffected; three classes demonstrated the three DSM-IV subtypes of ADHD, three subtypes showed different severities of RD, and two classes expressed a combination of RD and ADHD subtypes. LCA proved effective in refining the phenotypes of ADHD alone, RD alone, and ADHD–RD comorbidity, and its ability to classify them into homogenous groups based on clusters of symptoms, suggesting that the latent classes may be robust enough to use in molecular genetic studies. |
| first_indexed | 2025-11-14T08:14:30Z |
| format | Journal Article |
| id | curtin-20.500.11937-29454 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:14:30Z |
| publishDate | 2012 |
| publisher | John Wiley and Sons, Inc |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-294542017-09-13T15:52:27Z Phenotype refinement for comorbid Attention Deficit Hyperactivity Disorder and reading disability Sheikhi, A. Martin, Neilson Hay, David Piek, Jan latent class analysis genetics phenomics heterogeneity twins Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and reading disability (RD) is common; however, the heritability of this comorbidity is not well understood. This may be due to the complexity and heterogeneity of ADHD and RD phenotypes. Using alternative ADHD–RD sub-phenotypes instead of those arising from the DSM-IV may lead to greater success in the search for comorbid ADHD–RD susceptibility genes. Therefore, this study aims to refine ADHD–RD phenotypes into homogenous informative sub-phenotypes using latent class analysis (LCA). LCA was performed on 2,610 Australian twin families (6,535 individuals) in order to generate probabilistic genetically distinct classes that define ADHD–RD subtypes, including comorbidity, based on related symptom clusters. The LCA separated the phenotypes for ADHD and RD into nine classes. One class was unaffected; three classes demonstrated the three DSM-IV subtypes of ADHD, three subtypes showed different severities of RD, and two classes expressed a combination of RD and ADHD subtypes. LCA proved effective in refining the phenotypes of ADHD alone, RD alone, and ADHD–RD comorbidity, and its ability to classify them into homogenous groups based on clusters of symptoms, suggesting that the latent classes may be robust enough to use in molecular genetic studies. 2012 Journal Article http://hdl.handle.net/20.500.11937/29454 10.1002/ajmg.b.32119 John Wiley and Sons, Inc restricted |
| spellingShingle | latent class analysis genetics phenomics heterogeneity twins Sheikhi, A. Martin, Neilson Hay, David Piek, Jan Phenotype refinement for comorbid Attention Deficit Hyperactivity Disorder and reading disability |
| title | Phenotype refinement for comorbid Attention Deficit Hyperactivity Disorder and reading disability |
| title_full | Phenotype refinement for comorbid Attention Deficit Hyperactivity Disorder and reading disability |
| title_fullStr | Phenotype refinement for comorbid Attention Deficit Hyperactivity Disorder and reading disability |
| title_full_unstemmed | Phenotype refinement for comorbid Attention Deficit Hyperactivity Disorder and reading disability |
| title_short | Phenotype refinement for comorbid Attention Deficit Hyperactivity Disorder and reading disability |
| title_sort | phenotype refinement for comorbid attention deficit hyperactivity disorder and reading disability |
| topic | latent class analysis genetics phenomics heterogeneity twins |
| url | http://hdl.handle.net/20.500.11937/29454 |