Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations
Fungi are of primary ecological, biotechnological and economic importance. Many fundamental biological processes that are shared by animals and fungi are studied in fungi due to their experimental tractability. Many fungi are pathogens or mutualists and are model systems to analyse effector genes an...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Macmillan Publishers Limited
2011
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/29427 |
| _version_ | 1848752800294502400 |
|---|---|
| author | Rouxel, Thierry Graubert, Jonathan Hane, James K. Hoede, Claire Van de Wouw, Angela P. Couloux, Arnaud Dominguez, Victoria Anthouard, Véronique Bally, Pascal Bourras, Salim Cozijnsen, Anton J. Ciuffetti, Lynda M. Degrave, Alexandre Dilmaghani, Azita Duret, Laurent Fudal, Isabelle Goodwin, Stephen B. Gout, Lilian Glaser, Nicolas Linglin, Juliette Kema, Gert H. J. Lapalu, Nicolas Lawrence, Christopher B. May, Kim Meyer, Michel Ollivier, Bénédicte Poulain, Julie Schoch, Conrad L. Simon, Adeline Spatafora, Joseph W. Stachowiak, Anna Turgeon, B. Gillian Tyler, Brett M. Vincent, Delphine Weissenbach, Jean Amselem, Joëlle Quesneville, Hadi Oliver, Richard P. Wincker, Patrick Balesdent, Marie-Hélène Howlett, Barbara J. |
| author_facet | Rouxel, Thierry Graubert, Jonathan Hane, James K. Hoede, Claire Van de Wouw, Angela P. Couloux, Arnaud Dominguez, Victoria Anthouard, Véronique Bally, Pascal Bourras, Salim Cozijnsen, Anton J. Ciuffetti, Lynda M. Degrave, Alexandre Dilmaghani, Azita Duret, Laurent Fudal, Isabelle Goodwin, Stephen B. Gout, Lilian Glaser, Nicolas Linglin, Juliette Kema, Gert H. J. Lapalu, Nicolas Lawrence, Christopher B. May, Kim Meyer, Michel Ollivier, Bénédicte Poulain, Julie Schoch, Conrad L. Simon, Adeline Spatafora, Joseph W. Stachowiak, Anna Turgeon, B. Gillian Tyler, Brett M. Vincent, Delphine Weissenbach, Jean Amselem, Joëlle Quesneville, Hadi Oliver, Richard P. Wincker, Patrick Balesdent, Marie-Hélène Howlett, Barbara J. |
| author_sort | Rouxel, Thierry |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Fungi are of primary ecological, biotechnological and economic importance. Many fundamental biological processes that are shared by animals and fungi are studied in fungi due to their experimental tractability. Many fungi are pathogens or mutualists and are model systems to analyse effector genes and their mechanisms of diversification. In this study, we report the genome sequence of the phytopathogenic ascomycete Leptosphaeria maculans and characterize its repertoire of protein effectors. The L. maculans genome has an unusual bipartite structure with alternating distinct guanine and cytosine-equilibrated and adenine and thymine (AT)-rich blocks of homogenous nucleotide composition. The AT-rich blocks comprise one-third of the genome and contain effector genes and families of transposable elements, both of which are affected by repeat-induced point mutation, a fungal-specific genome defence mechanism. This genomic environment for effectors promotes rapid sequence diversification and underpins the evolutionary potential of the fungus to adapt rapidly to novel host-derived constraints. |
| first_indexed | 2025-11-14T08:14:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-29427 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:14:22Z |
| publishDate | 2011 |
| publisher | Macmillan Publishers Limited |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-294272018-05-04T01:28:23Z Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations Rouxel, Thierry Graubert, Jonathan Hane, James K. Hoede, Claire Van de Wouw, Angela P. Couloux, Arnaud Dominguez, Victoria Anthouard, Véronique Bally, Pascal Bourras, Salim Cozijnsen, Anton J. Ciuffetti, Lynda M. Degrave, Alexandre Dilmaghani, Azita Duret, Laurent Fudal, Isabelle Goodwin, Stephen B. Gout, Lilian Glaser, Nicolas Linglin, Juliette Kema, Gert H. J. Lapalu, Nicolas Lawrence, Christopher B. May, Kim Meyer, Michel Ollivier, Bénédicte Poulain, Julie Schoch, Conrad L. Simon, Adeline Spatafora, Joseph W. Stachowiak, Anna Turgeon, B. Gillian Tyler, Brett M. Vincent, Delphine Weissenbach, Jean Amselem, Joëlle Quesneville, Hadi Oliver, Richard P. Wincker, Patrick Balesdent, Marie-Hélène Howlett, Barbara J. Molecular biology Microbiology Bioinformatics Biological Sciences Fungi are of primary ecological, biotechnological and economic importance. Many fundamental biological processes that are shared by animals and fungi are studied in fungi due to their experimental tractability. Many fungi are pathogens or mutualists and are model systems to analyse effector genes and their mechanisms of diversification. In this study, we report the genome sequence of the phytopathogenic ascomycete Leptosphaeria maculans and characterize its repertoire of protein effectors. The L. maculans genome has an unusual bipartite structure with alternating distinct guanine and cytosine-equilibrated and adenine and thymine (AT)-rich blocks of homogenous nucleotide composition. The AT-rich blocks comprise one-third of the genome and contain effector genes and families of transposable elements, both of which are affected by repeat-induced point mutation, a fungal-specific genome defence mechanism. This genomic environment for effectors promotes rapid sequence diversification and underpins the evolutionary potential of the fungus to adapt rapidly to novel host-derived constraints. 2011 Journal Article http://hdl.handle.net/20.500.11937/29427 10.1038/ncomms1189 http://creativecommons.org/licenses/by-nc-nd/3.0/ Macmillan Publishers Limited fulltext |
| spellingShingle | Molecular biology Microbiology Bioinformatics Biological Sciences Rouxel, Thierry Graubert, Jonathan Hane, James K. Hoede, Claire Van de Wouw, Angela P. Couloux, Arnaud Dominguez, Victoria Anthouard, Véronique Bally, Pascal Bourras, Salim Cozijnsen, Anton J. Ciuffetti, Lynda M. Degrave, Alexandre Dilmaghani, Azita Duret, Laurent Fudal, Isabelle Goodwin, Stephen B. Gout, Lilian Glaser, Nicolas Linglin, Juliette Kema, Gert H. J. Lapalu, Nicolas Lawrence, Christopher B. May, Kim Meyer, Michel Ollivier, Bénédicte Poulain, Julie Schoch, Conrad L. Simon, Adeline Spatafora, Joseph W. Stachowiak, Anna Turgeon, B. Gillian Tyler, Brett M. Vincent, Delphine Weissenbach, Jean Amselem, Joëlle Quesneville, Hadi Oliver, Richard P. Wincker, Patrick Balesdent, Marie-Hélène Howlett, Barbara J. Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations |
| title | Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations |
| title_full | Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations |
| title_fullStr | Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations |
| title_full_unstemmed | Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations |
| title_short | Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations |
| title_sort | effector diversification within compartments of the leptosphaeria maculans genome affected by repeat-induced point mutations |
| topic | Molecular biology Microbiology Bioinformatics Biological Sciences |
| url | http://hdl.handle.net/20.500.11937/29427 |