Long-term mortality risks associated with mild anaemia in older persons: The Busselton health study
Background: Up to 25% of older people in the USA and other Western countries are anaemic by World Health Organization (WHO) criteria. The objective of this study was to examine the long-term relationships of haemoglobin concentration with all-cause and cause-specific mortality in a community-based s...
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| Format: | Journal Article |
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Oxford University Press
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/29343 |
| _version_ | 1848752777868607488 |
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| author | Chalmers, K. Knuiman, M. Divitini, M. Bruce, D. Olynyk, John Milward, E. |
| author_facet | Chalmers, K. Knuiman, M. Divitini, M. Bruce, D. Olynyk, John Milward, E. |
| author_sort | Chalmers, K. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Up to 25% of older people in the USA and other Western countries are anaemic by World Health Organization (WHO) criteria. The objective of this study was to examine the long-term relationships of haemoglobin concentration with all-cause and cause-specific mortality in a community-based sample of Australian adults surveyed in 1978. Methods: A community survey of 2,194 adults aged 40+ years in Busselton, Western Australia in 1978 with mortality follow-up to 2001. Cox regression models were used to investigate the relationships of haemoglobin as a continuous measure and anaemia by WHO criteria (women <12 g/dl (7.5 mmol/l); men <13 g/dl (8.1 mmol/l)) with all-cause, cardiovascular and cancer mortality. Results: Anaemia was predominantly mild (>10 g/dl) and normocytic. There was an increased risk of death from all causes and from cancer for men with low haemoglobin. Cancers were predominantly of the prostate and genito-urinary organs, and to a lesser extent the gastrointestinal tract. There was no increased risk of all cause or cancer death in women. Conclusion: Mild, normocytic anaemia is associated with survival reductions in middle-aged and older men, where it often occurs with prostate, gastrointestinal and other cancers, and should be investigated to exclude treatable causes. |
| first_indexed | 2025-11-14T08:14:01Z |
| format | Journal Article |
| id | curtin-20.500.11937-29343 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:14:01Z |
| publishDate | 2012 |
| publisher | Oxford University Press |
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| spelling | curtin-20.500.11937-293432017-09-13T15:52:26Z Long-term mortality risks associated with mild anaemia in older persons: The Busselton health study Chalmers, K. Knuiman, M. Divitini, M. Bruce, D. Olynyk, John Milward, E. Busselton Health Study haemoglobin anaemia mortality older people ageing Background: Up to 25% of older people in the USA and other Western countries are anaemic by World Health Organization (WHO) criteria. The objective of this study was to examine the long-term relationships of haemoglobin concentration with all-cause and cause-specific mortality in a community-based sample of Australian adults surveyed in 1978. Methods: A community survey of 2,194 adults aged 40+ years in Busselton, Western Australia in 1978 with mortality follow-up to 2001. Cox regression models were used to investigate the relationships of haemoglobin as a continuous measure and anaemia by WHO criteria (women <12 g/dl (7.5 mmol/l); men <13 g/dl (8.1 mmol/l)) with all-cause, cardiovascular and cancer mortality. Results: Anaemia was predominantly mild (>10 g/dl) and normocytic. There was an increased risk of death from all causes and from cancer for men with low haemoglobin. Cancers were predominantly of the prostate and genito-urinary organs, and to a lesser extent the gastrointestinal tract. There was no increased risk of all cause or cancer death in women. Conclusion: Mild, normocytic anaemia is associated with survival reductions in middle-aged and older men, where it often occurs with prostate, gastrointestinal and other cancers, and should be investigated to exclude treatable causes. 2012 Journal Article http://hdl.handle.net/20.500.11937/29343 10.1093/ageing/afs150 Oxford University Press fulltext |
| spellingShingle | Busselton Health Study haemoglobin anaemia mortality older people ageing Chalmers, K. Knuiman, M. Divitini, M. Bruce, D. Olynyk, John Milward, E. Long-term mortality risks associated with mild anaemia in older persons: The Busselton health study |
| title | Long-term mortality risks associated with mild anaemia in older persons: The Busselton health study |
| title_full | Long-term mortality risks associated with mild anaemia in older persons: The Busselton health study |
| title_fullStr | Long-term mortality risks associated with mild anaemia in older persons: The Busselton health study |
| title_full_unstemmed | Long-term mortality risks associated with mild anaemia in older persons: The Busselton health study |
| title_short | Long-term mortality risks associated with mild anaemia in older persons: The Busselton health study |
| title_sort | long-term mortality risks associated with mild anaemia in older persons: the busselton health study |
| topic | Busselton Health Study haemoglobin anaemia mortality older people ageing |
| url | http://hdl.handle.net/20.500.11937/29343 |