Topical Microneedle Drug Delivery Enhanced with Magnetophoresis
Proteins and peptides are coming of age as targeted biological therapies. A broad range of peptides have now been approved by the FDA and other regulatory agencies for use as therapeutics. Likewise, large proteins such as infliximab and botox are commonly used to treat skin conditions. The most wide...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Book Chapter |
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The Royal Society of Chemistry
2014
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| Online Access: | http://pubs.rsc.org/en/content/chapter/bk9781849733984-00169/978-1-84973-463-9#!divabstract http://hdl.handle.net/20.500.11937/29263 |
| _version_ | 1848752756944273408 |
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| author | Prow, T. Mohammed, Y. Ansaldo, A. Benson, Heather |
| author2 | Keith R. Brain |
| author_facet | Keith R. Brain Prow, T. Mohammed, Y. Ansaldo, A. Benson, Heather |
| author_sort | Prow, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Proteins and peptides are coming of age as targeted biological therapies. A broad range of peptides have now been approved by the FDA and other regulatory agencies for use as therapeutics. Likewise, large proteins such as infliximab and botox are commonly used to treat skin conditions. The most widely used delivery approach for peptides and proteins is parenteral injection, largely due to oral instability and the lack of a suitable alternative. Intense research is being done to improve the short half-lives of these biological therapies and find suitable alternative delivery routes. Transdermal delivery holds promise as an improved delivery route because the skin has low levels of enzymatic activity and can help drugs avoid first-pass metabolism. Further, topical delivery has the potential for direct treatment of skin disease for both therapeutic and cosmetic applications. |
| first_indexed | 2025-11-14T08:13:41Z |
| format | Book Chapter |
| id | curtin-20.500.11937-29263 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:13:41Z |
| publishDate | 2014 |
| publisher | The Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-292632023-02-27T07:34:30Z Topical Microneedle Drug Delivery Enhanced with Magnetophoresis Prow, T. Mohammed, Y. Ansaldo, A. Benson, Heather Keith R. Brain Robert P Chilcott Proteins and peptides are coming of age as targeted biological therapies. A broad range of peptides have now been approved by the FDA and other regulatory agencies for use as therapeutics. Likewise, large proteins such as infliximab and botox are commonly used to treat skin conditions. The most widely used delivery approach for peptides and proteins is parenteral injection, largely due to oral instability and the lack of a suitable alternative. Intense research is being done to improve the short half-lives of these biological therapies and find suitable alternative delivery routes. Transdermal delivery holds promise as an improved delivery route because the skin has low levels of enzymatic activity and can help drugs avoid first-pass metabolism. Further, topical delivery has the potential for direct treatment of skin disease for both therapeutic and cosmetic applications. 2014 Book Chapter http://hdl.handle.net/20.500.11937/29263 http://pubs.rsc.org/en/content/chapter/bk9781849733984-00169/978-1-84973-463-9#!divabstract The Royal Society of Chemistry restricted |
| spellingShingle | Prow, T. Mohammed, Y. Ansaldo, A. Benson, Heather Topical Microneedle Drug Delivery Enhanced with Magnetophoresis |
| title | Topical Microneedle Drug Delivery Enhanced with Magnetophoresis |
| title_full | Topical Microneedle Drug Delivery Enhanced with Magnetophoresis |
| title_fullStr | Topical Microneedle Drug Delivery Enhanced with Magnetophoresis |
| title_full_unstemmed | Topical Microneedle Drug Delivery Enhanced with Magnetophoresis |
| title_short | Topical Microneedle Drug Delivery Enhanced with Magnetophoresis |
| title_sort | topical microneedle drug delivery enhanced with magnetophoresis |
| url | http://pubs.rsc.org/en/content/chapter/bk9781849733984-00169/978-1-84973-463-9#!divabstract http://hdl.handle.net/20.500.11937/29263 |