1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry
Purines can be considered as the most ubiquitous and functional N-heterocyclic compounds in nature. Structural modifications of natural purines, particularly using isosteric ring systems, have been in the focus of many drug discovery programs. Fusion of 1,3,5-triazine ring with pyrrole, pyrazole, im...
| Main Authors: | , |
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| Format: | Journal Article |
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Elsevier Masson
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/28486 |
| _version_ | 1848752550152503296 |
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| author | Lim, Felicia Phei Lin Dolzhenko, Anton |
| author_facet | Lim, Felicia Phei Lin Dolzhenko, Anton |
| author_sort | Lim, Felicia Phei Lin |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purines can be considered as the most ubiquitous and functional N-heterocyclic compounds in nature. Structural modifications of natural purines, particularly using isosteric ring systems, have been in the focus of many drug discovery programs. Fusion of 1,3,5-triazine ring with pyrrole, pyrazole, imidazole, 1,2,3-triazole or 1,2,4-triazole results in seven bicyclic heterocyclic systems isosteric to purine. Application of the isosterism concept for the development of new compounds with therapeutic potential in areas involving purinergic regulation or purine metabolism led to significant advances in medicinal chemistry of the azolo[1,3,5]triazines. These 1,3,5-triazine-based purine-like scaffolds significantly increase level of molecular diversity and allow covering chemical space in the important areas of medicinal chemistry. Some of these azolo[1,3,5]triazine systems have become privileged scaffolds in the development of inhibitors of various kinases, phosphodiesterase, xanthine oxidase, and thymidine phosphorylase, antagonists of adenosine and corticotropin-releasing hormone receptors, anticancer and antiviral agents. |
| first_indexed | 2025-11-14T08:10:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-28486 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:10:24Z |
| publishDate | 2014 |
| publisher | Elsevier Masson |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-284862017-09-13T15:19:35Z 1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry Lim, Felicia Phei Lin Dolzhenko, Anton Purine Antiviral Anticancer Triazine Isostere Enzyme inhibitor Purines can be considered as the most ubiquitous and functional N-heterocyclic compounds in nature. Structural modifications of natural purines, particularly using isosteric ring systems, have been in the focus of many drug discovery programs. Fusion of 1,3,5-triazine ring with pyrrole, pyrazole, imidazole, 1,2,3-triazole or 1,2,4-triazole results in seven bicyclic heterocyclic systems isosteric to purine. Application of the isosterism concept for the development of new compounds with therapeutic potential in areas involving purinergic regulation or purine metabolism led to significant advances in medicinal chemistry of the azolo[1,3,5]triazines. These 1,3,5-triazine-based purine-like scaffolds significantly increase level of molecular diversity and allow covering chemical space in the important areas of medicinal chemistry. Some of these azolo[1,3,5]triazine systems have become privileged scaffolds in the development of inhibitors of various kinases, phosphodiesterase, xanthine oxidase, and thymidine phosphorylase, antagonists of adenosine and corticotropin-releasing hormone receptors, anticancer and antiviral agents. 2014 Journal Article http://hdl.handle.net/20.500.11937/28486 10.1016/j.ejmech.2014.07.112 Elsevier Masson restricted |
| spellingShingle | Purine Antiviral Anticancer Triazine Isostere Enzyme inhibitor Lim, Felicia Phei Lin Dolzhenko, Anton 1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry |
| title | 1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry |
| title_full | 1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry |
| title_fullStr | 1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry |
| title_full_unstemmed | 1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry |
| title_short | 1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry |
| title_sort | 1,3,5-triazine-based analogues of purine: from isosteres to privileged scaffolds in medicinal chemistry |
| topic | Purine Antiviral Anticancer Triazine Isostere Enzyme inhibitor |
| url | http://hdl.handle.net/20.500.11937/28486 |