Rett syndrome: Establishing a novel outcome measure for walking activity in an era of clinical trials for rare disorders
Background: Rett syndrome is a pervasive neurological disorder with impaired gait as one criterion. This study investigated the capacity of three accelerometer-type devices to measure walking activity in Rett syndrome. Methods: Twenty-six participants (mean 18 years, SD 8) wore an Actigraph, ActivPA...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Taylor and Francis Ltd
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/28124 |
| _version_ | 1848752451229843456 |
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| author | Downs, Jennepher Leonard, H. Jacoby, P. Brisco, L. Baikie, G. Hill, Kylie |
| author_facet | Downs, Jennepher Leonard, H. Jacoby, P. Brisco, L. Baikie, G. Hill, Kylie |
| author_sort | Downs, Jennepher |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Rett syndrome is a pervasive neurological disorder with impaired gait as one criterion. This study investigated the capacity of three accelerometer-type devices to measure walking activity in Rett syndrome. Methods: Twenty-six participants (mean 18 years, SD 8) wore an Actigraph, ActivPAL and StepWatch Activity Monitor (SAM) during a video-taped session of activities. Agreement was determined between step-counts derived from each accelerometer and observation. Repeatability of SAM-derived step counts was determined using pairs of one-minute epochs during which the same participant was observed to walk with the same cadence. Results: The mean difference (limit of agreement) for the Actigraph, ActivPAL and SAM were −41 (SD 33), −16 (SD 21) and −1 (SD 16) steps/min, respectively. Agreement was influenced by a device/cadence interaction (p < 0.001) with greater under-recording at higher cadences. For SAM data, repeatability of step-count pairs was excellent (intraclass correlation coefficient 0.91, 95% CI 0.79–0.96). The standard error of measurement was 6 steps/min and we would be 95% confident that a change ≥17 steps/min would be greater than within-subject measurement error. Conclusions: The capacity of the SAM to measure physical activity in Rett syndrome allows focus on participation-based activities in clinical practice and clinical trials. |
| first_indexed | 2025-11-14T08:08:50Z |
| format | Journal Article |
| id | curtin-20.500.11937-28124 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:08:50Z |
| publishDate | 2015 |
| publisher | Taylor and Francis Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-281242017-09-13T15:14:32Z Rett syndrome: Establishing a novel outcome measure for walking activity in an era of clinical trials for rare disorders Downs, Jennepher Leonard, H. Jacoby, P. Brisco, L. Baikie, G. Hill, Kylie Background: Rett syndrome is a pervasive neurological disorder with impaired gait as one criterion. This study investigated the capacity of three accelerometer-type devices to measure walking activity in Rett syndrome. Methods: Twenty-six participants (mean 18 years, SD 8) wore an Actigraph, ActivPAL and StepWatch Activity Monitor (SAM) during a video-taped session of activities. Agreement was determined between step-counts derived from each accelerometer and observation. Repeatability of SAM-derived step counts was determined using pairs of one-minute epochs during which the same participant was observed to walk with the same cadence. Results: The mean difference (limit of agreement) for the Actigraph, ActivPAL and SAM were −41 (SD 33), −16 (SD 21) and −1 (SD 16) steps/min, respectively. Agreement was influenced by a device/cadence interaction (p < 0.001) with greater under-recording at higher cadences. For SAM data, repeatability of step-count pairs was excellent (intraclass correlation coefficient 0.91, 95% CI 0.79–0.96). The standard error of measurement was 6 steps/min and we would be 95% confident that a change ≥17 steps/min would be greater than within-subject measurement error. Conclusions: The capacity of the SAM to measure physical activity in Rett syndrome allows focus on participation-based activities in clinical practice and clinical trials. 2015 Journal Article http://hdl.handle.net/20.500.11937/28124 10.3109/09638288.2014.993436 Taylor and Francis Ltd fulltext |
| spellingShingle | Downs, Jennepher Leonard, H. Jacoby, P. Brisco, L. Baikie, G. Hill, Kylie Rett syndrome: Establishing a novel outcome measure for walking activity in an era of clinical trials for rare disorders |
| title | Rett syndrome: Establishing a novel outcome measure for walking activity in an era of clinical trials for rare disorders |
| title_full | Rett syndrome: Establishing a novel outcome measure for walking activity in an era of clinical trials for rare disorders |
| title_fullStr | Rett syndrome: Establishing a novel outcome measure for walking activity in an era of clinical trials for rare disorders |
| title_full_unstemmed | Rett syndrome: Establishing a novel outcome measure for walking activity in an era of clinical trials for rare disorders |
| title_short | Rett syndrome: Establishing a novel outcome measure for walking activity in an era of clinical trials for rare disorders |
| title_sort | rett syndrome: establishing a novel outcome measure for walking activity in an era of clinical trials for rare disorders |
| url | http://hdl.handle.net/20.500.11937/28124 |