A New Method for Estimating the Importance of Hydrophobic Groups in the Binding Site of a Protein

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A New Method for Estimating the Importance of Hydrophobic Groups in the Binding Site of a Protein

Interactions between the hydrophobic regions of a binding site and those of a complementary ligand are often observed to provide the driving force for binding. We present a new method for the analysis of hydrophobic regions in the binding site of a protein that considers not only atom type but also...

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Bibliographic Details
Main Authors:	Kelly, M., Mancera, Ricardo
Format:	Journal Article
Published:	ACS Publications 2005
Subjects:	binding site Hydrophobic interaction genetic algorithm drug design ligand-protein interactions
Online Access:	http://hdl.handle.net/20.500.11937/28078

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